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Article
Entacapone improves the pharmacokinetic and therapeutic response of controlled release levodopa/carbidopa in Parkinson’s patients
The aim of this trial was to evaluate the effects of the COMT inhibitor entacapone on both the pharmacokinetic profile and clinical efficacy of controlled release levodopa in Parkinson’s disease (PD) patients....
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Article
Increased plasma bilirubin in Parkinson patients on L-dopa: evidence against the free radical hypothesis?
Oxidative damage by free radicals may contribute to the etiology of Parkinson's disease (PD), and increased oxidative stress in the nigral cells of PD patients may occur following L-dopa treatment, prompting s...
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Article
Survival in multiple system atrophy: a study of prognostic factors in 59 cases
The various clinical features of multiple system atrophy (MSA) make the diagnosis of the disease difficult, especially in its early stages, when signs of differentiated neuroanatomical system involvement have ...
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Article
Progression of motor and cognitive impairment in Parkinson's disease
We performed a longitudinal study (mean follow-up 86.7 months) to evaluate motor and mental deterioration in patients with Parkinson's disease. Of the original 91 patients, only 61 could be re-examined 7 years...
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Article
Differing patterns of psychiatric impairment in Alzheimer and demented parkinsonian patients
Psychiatric symptoms were investigated and compared in 95 patients with Alzheimer type dementia (DAT) and in 39 patients with Parkinson's disease with dementia (PD-D). The diagnosis of the dementia and psychia...
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Article
Spasmodic dystonic laterocollis in familial cerebellar ataxia
The case of a woman affected by familial ataxia who developed marked spasmodic laterocollis is described. As this appears to be an uncommon association, it is worth reporting one more case.
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Article
Botulinum toxin treatment in patients with focal dystonia and hemifacial spasm. A multicenter study of the Italian Movement Disorder Group
In six Centers belonging to the Italian Movement Disorder Study Group, the efficacy of botulinum toxin treatment was evaluated in an open collaborative study in 251 patients with focal dystonia and hemifacial ...
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Article
Hemichorea due to a cavernous angioma of the caudate. Case report of an aged patient
A 75 year old man presented left hemichorea due to a cavernous angioma of the head of the contralateral caudate. Cavernous angiomas of the basal ganglia are an infrequent cause of hemichorea especially in olde...
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Article
Book reviews
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Chapter
Course of Motor and Cognitive Impairment in Huntington’s Chorea
Motor impairment, mental decay and psychopathological abnormalities all contribute to functional disability in Huntington’s Chorea (HC) (1–3) though Mayeux et al (4) concluded that a major role is played by in...
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Chapter and Conference Paper
Adrenal Medulla Autograft in Caudate Nucleus as Treatment for Parkinson Disease
The personal experience of four Parkinson’s disease patients operated on with adrenal medulla autograft in the caudate nucleus is reported. Results on long term, possible only in two patients, are moderately f...
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Chapter
Treatment of Motor Fluctuations in Parkinson’s Disease: Controlled Release Preparations
The fundamental problem in the treatment of Parkinson’s disease is the appearance of motor fluctuations after long-term drug therapy (long-term L-dopa treatment syndrome, LTS, Marsden and Parkes, 1976). The cl...
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Article
Branched-chain amino acids in the treatment of amyotrophic lateral sclerosis
Thirty-two patients affected by amyotrophic lateral sclerosis (ALS) were included in a controlled, open therapeutic trial with branched chain amino acids (BCAA). Patients with bulbar muscle involvement were ev...
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Article
Deprenyl in Parkinson disease: personal experience
The aim of this study was to evaluate the therapeutic activity of Deprenyl in patients with Parkinson disease already being treated with L-Dopa+PDI. 15 selected patients were allocated to two groups according ...
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Chapter
Neuroendocrine Control of Pituitary Function in Extrapiramidal Disorders
The purpose of this study was to reconsider the functional status of the hypothalamus-pituitary axis in diseases of the extrapyramidal system. The theme of the paper is behavior of the secretion of growth horm...
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Article
Book reviews
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Article
Bromocriptine — lisuride cross tolerance
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Article
Idiopathic dystonia: Neuropharmacological study
A total of 15 patients affected by idiopathic dystonia (7 with generalized and 8 with focal or segmental dystonia) were subjected to therapy with bromocriptine at low doses, pimozide and trihexyphenidyl. The s...
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Article
Book reviews
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Article
Book reviews
