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Article
Gene regulation and priming by topoisomerase IIα in embryonic stem cells
Topoisomerases resolve torsional stress, while their function in gene regulation, especially during cellular differentiation, remains unknown. Here we find that the expression of topo II isoforms, topoisomeras...
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Article
Open AccessMap** gene regulatory circuitry of Pax6 during neurogenesis
Pax6 is a highly conserved transcription factor among vertebrates and is important in various aspects of the central nervous system development. However, the gene regulatory circuitry of Pax6 underlying these ...
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Article
Open AccessThe transcriptome of mouse central nervous system myelin
Rapid nerve conduction in the CNS is facilitated by insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body. Myelin is turned over and adapted throughout life; ho...
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Article
Genetic determinants and epigenetic effects of pioneer-factor occupancy
Transcription factors (TFs) direct developmental transitions by binding to target DNA sequences, influencing gene expression and establishing complex gene-regultory networks. To systematically determine the mo...
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Article
Open AccessDifferential regulation of OCT4 targets facilitates reacquisition of pluripotency
Ectopic transcription factor expression enables reprogramming of somatic cells to pluripotency, albeit with generally low efficiency. Despite steady progress in the field, the exact molecular mechanisms that c...
