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Article
Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states
Metabolism negotiates cell-endogenous requirements of energy, nutrients and building blocks with the immediate environment to enable various processes, including growth and differentiation. While there is an i...
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Article
Acute BAF perturbation causes immediate changes in chromatin accessibility
Cancer-associated, loss-of-function mutations in genes encoding subunits of the BRG1/BRM-associated factor (BAF) chromatin-remodeling complexes1–8 often cause drastic chromatin accessibility changes, especially i...
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Article
Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers
Aberrations in genes coding for subunits of the BRG1/BRM associated factor (BAF) chromatin remodeling complexes are highly abundant in human cancers. Currently, it is not understood how these mostly loss-of-fu...
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Article
MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation
The histone acetyl reader bromodomain-containing protein 4 (BRD4) is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe...
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Article
Open AccessMap** gene regulatory circuitry of Pax6 during neurogenesis
Pax6 is a highly conserved transcription factor among vertebrates and is important in various aspects of the central nervous system development. However, the gene regulatory circuitry of Pax6 underlying these ...
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Article
Plasma Homovanillic Acid: A Significant Association with Alcoholism is Independent of a Functional Polymorphism of the Human Catechol-O-Methyltransferase Gene
The central dopamine system seems to influence addictive disorders. Plasma homovanillic acid (HVA) is an indicator of central dopaminergic activity. In this study the hypothesis that plasma HVA is associated w...
