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Article
Open AccessMHY4571, a novel diarylcyclohexanone derivative, exerts anti-cancer activity by regulating the PKA-cAMP-response element-binding protein pathway in squamous cell lung cancer
The protein kinase A (PKA)/cAMP response element-binding protein (CREB) has been suggested to be related to the inhibition of the proliferation of non-small cell lung cancer (NSCLC) cells. This study aimed to ...
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Article
BrRH37, a Cabbage (Brassica rapa) DEAD-Box RNA Helicase, Confers Drought Tolerance and ABA Response in Transgenic Arabidopsis Plants
RNA helicases (RHs) are cellular proteins that help in the regulation of post-transcriptional mRNA metabolism, which is vital for the response of crops to abiotic stresses. In this study, we determined the fun...
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Article
Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial
Neurofibromatosis type 1 (NF1) plexiform neurofibromas (PNs) are progressive, multicellular neoplasms that cause morbidity and may transform to sarcoma. Treatment of Nf1fl/fl;Postn-Cre mice with cabozantinib, an ...
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Article
Open AccessCa2+-activated mitochondrial biogenesis and functions improve stem cell fate in Rg3-treated human mesenchymal stem cells
Although mitochondrial functions are essential for cell survival, their critical roles in stem cell fate, including proliferation, differentiation, and senescence, remain elusive. Ginsenoside Rg3 exhibits vari...
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Article
A La-Related Protein LaRP6a Delays Flowering of Arabidopsis thaliana by Upregulating FLC Transcript Levels
La-related proteins (LaRPs) are RNA-binding proteins (RBPs) that contain a La-type helix-turn-helix (HTH) domain and are found in all eukaryotes, including plants, animals, and yeasts. Although the functions o...
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Article
Open AccessInduction of E6AP by microRNA-302c dysregulation inhibits TGF-β-dependent fibrogenesis in hepatic stellate cells
Hepatic stellate cells (HSCs) are essential for liver fibrosis. E6 associated protein (E6AP) is one of the E3-ubiquitin-protein ligase and has been studied in proliferation and cellular stress. Currently, no i...
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Article
Open Access15 years journey of idiopathic pulmonary arterial hypertension with BMPR2 mutation
Pulmonary arterial hypertension (PAH) is known as one of diseases with the worst prognosis. Recently, targeted PAH drugs have been developed and approved for use; therefore, the treatment strategy and goals ha...
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Article
Open AccessA Nationwide multicenter registry and biobank program for deep phenoty** of idiopathic and hereditary pulmonary arterial hypertension in Korea: the PAH platform for deep phenoty** in Korean subjects (PHOENIKS) cohort
Pulmonary arterial hypertension (PAH) is a progressive, chronic disease without curative treatment. Large registry data of these patient populations have been published, although, phenotypic variants within ea...
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Article
Open AccessSPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis
During ligand-mediated receptor endocytosis, the small GTPase Rab5 functions in vesicle fusion and trafficking. Rab5 activation is known to require interactions with its guanine nucleotide-exchange factors (GE...
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Article
Open AccessA chloroplast-targeted pentatricopeptide repeat protein PPR287 is crucial for chloroplast function and Arabidopsis development
Even though the roles of pentatricopeptide repeat (PPR) proteins are essential in plant organelles, the function of many chloroplast-targeted PPR proteins remains unknown. Here, we characterized the function o...
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A Chloroplast-targeted S1 RNA-binding Domain Protein Plays a Role in Arabidopsis Response to Diverse Abiotic Stresses
Although accumulating evidence points to the essential roles of nucleus-encoded chloroplast S1 domain-containing proteins (SDPs) in chloroplast RNA metabolism and plant development, functions of chloroplast SD...
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Article
Development of Colorimetric Paper Sensor for Pesticide Detection Using Competitive-inhibiting Reaction
Contamination by pesticides is an ever-increasing problem associated with fields of environmental management and healthcare. Accordingly, appropriate treatments are in demand. Pesticide detection methods have ...
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Article
The Effect of Fibronectin-Immobilized Microgrooved Titanium Substrata on Cell Proliferation and Expression of Genes and Proteins in Human Gingival Fibroblasts
We aimed to determine the effect of fibronectin (FN)-immobilized microgrooved titanium (Ti) on human gingival fibroblast proliferation, gene expression and protein expression.
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Article
Open AccessSDE5, a putative RNA export protein, participates in plant innate immunity through a flagellin-dependent signaling pathway in Arabidopsis
In eukaryotes, RNA silencing, mediated by small interfering RNAs, is an evolutionarily widespread and versatile silencing mechanism that plays an important role in various biological processes. Increasing evid...
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Article
Identification and functional characterization of Siberian wild rye (Elymus sibiricus L.) small heat shock protein 16.9 gene (EsHsp16.9) conferring diverse stress tolerance in prokaryotic cells
Small heat shock proteins (Hsps) protect against stress-inducible denaturation of substrates. Our objectives were to clone and examine the mRNA expression of the Hsp16.9 gene from Siberian wild rye grown under di...
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Article
Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase
Neurofibromatosis type 1 (NF1) is associated with social dysfunction in children. Here the authors show that Nf1 heterozygous mice have deficits in social memory associated with alterations in amygdala plasticity...
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Article
Open AccessPhysical properties and biological/odontogenic effects of an experimentally developed fast-setting α-tricalcium phosphate-based pulp cap** material
Recently, fast-setting α-tricalcium-phosphate (TCP) cement was developed for use in the pulp cap** process. The aim of this study was to investigate the physical properties and biological effects of α-TCP ce...
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Article
Regulation of RNA metabolism in plant development and stress responses
Posttranscriptional regulation of RNA metabolism, including RNA processing, splicing, editing, transport, translational control and turnover, is a key regulatory process in plant growth, development, and stres...
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Article
Correction: Corrigendum: Release of SOS2 kinase from sequestration with GIGANTEA determines salt tolerance in Arabidopsis
Nature Communications 4: Article number: 1352 (2013); Published 15 January 2013; Updated 7 May 2013 An image in Fig. 5a in this Article, showing CBB-stained bands for the ‘Phosphatase’ group, was inadvertently...
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Article
Release of SOS2 kinase from sequestration with GIGANTEA determines salt tolerance in Arabidopsis
Environmental challenges to plants typically entail retardation of vegetative growth and delay or cessation of flowering. Here we report a link between the flowering time regulator, GIGANTEA (GI), and adaptati...
