15 Result(s)
within
Stephen L. Helfand
English
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Article
The role of retrotransposable elements in ageing and age-associated diseases
The genomes of virtually all organisms contain repetitive sequences that are generated by the activity of transposable elements (transposons). Transposons are mobile genetic elements that can move from one gen...
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Article
Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
L1 drives IFN in senescent cells and promotes age-associated inflammation
Retrotransposable elements are deleterious at many levels, and the failure of host surveillance systems for these elements can thus have negative consequences. However, the contribution of retrotransposon acti...
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Chapter
Contribution of Retrotransposable Elements to Aging
Retrotransposable elements (RTEs) are abundant in the genomes of most species and continue to evolve and adapt to the defense mechanisms of their host cells. RTEs have contributed to the evolution of their hos...
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Article
Open AccessA somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan
In gonadal tissues, the Piwi-interacting (piRNA) pathway preserves genomic integrity by employing 23–29 nucleotide (nt) small RNAs complexed with argonaute proteins to suppress parasitic mobile sequences of DN...
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Article
RNA editing regulates transposon-mediated heterochromatic gene silencing
Heterochromatin formation drives epigenetic mechanisms associated with silenced gene expression. Repressive heterochromatin is established through the RNA interference pathway, triggered by double-stranded RNA...
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Protocol
Genetic and Biochemical Tools for Investigating Sirtuin Function in Drosophila melanogaster
Drosophila melanogaster is one of the most widely used genetic model systems in biology. The ease of working in an invertebrate model system allows the design and execution of many experiments th...
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Article
Correction: Corrigendum: Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Nature 430, 686–689 (2004). There are errors in Fig. 4 of this Letter: panels a and d are correct; however, panel c was incorrectly published as a duplicate of panel a, and panel b should have been labelled as...
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Article
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases2,3. Sirtui...
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Article
Functional Characterization of a Drosophila Mitochondrial Uncoupling Protein
Sequence alignment of conserved signature motifs predicts the existence of the uncoupling protein 5 (UCP5)/brain mitochondrial carrier protein (BMCP1) homologue in Drosophila melanogaster (Hanak P. and Jezek P. (...
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Article
Rejuvenating views of the ageing process
Commonly held assumptions about the ageing process have guided and directed research in this important area over many years. Recent evidence, however, from disciplines as diverse as molecular genetics, clinica...
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Article
Cu, Zn superoxide dismutase deficiencyaccelerates the time course of an age-related markerin Drosophila melanogaster
In the oxidative stress hypothesis of aging therandom accumulation of oxidative damage over time ispostulated to cause aging. The pace at whichoxidative damage accrues determines the rate of aging,but it is le...
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Chapter
Regulation of Gene Expression During Aging
The phenomenon of aging is generally believed to be genetically determined and environmentally modulated. Although genetics plays a major role in the determination of life span, the mechanisms by which genetic...
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Article
Segmental distribution of bithorax complex proteins during Drosophila development
The Ubx and bxd transcription units comprise a single functional domain in the bithorax complex of Drosophila melanogaster. The segmental distributions and nuclear localization of proteins encoded by the Ubx unit...
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Article
Oxygen intermediates are triggered early in the cytolytic pathway of human NK cells
The mechanism of tumour cell destruction by natural killer (NK) cells or other lymphocytes is not understood. NK cells appear to represent a primitive anti-tumour surveillance system more analogous to macropha...
