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Article
The inter-relationship between delirium and dementia: the importance of delirium prevention
Delirium and dementia are two frequent causes of cognitive impairment among older adults and have a distinct, complex and interconnected relationship. Delirium is an acute confusional state characterized by in...
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Article
Assessment of potential selection bias in neuroimaging studies of postoperative delirium and cognitive decline: lessons from the SAGES study
Due to cost and participant burden, neuroimaging studies are often performed in relatively small samples of voluntary participants. This may lead to selection bias. It is important to identify factors associa...
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Article
Open AccessA structured ICA-based process for removing auditory evoked potentials
Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs), recorded using electroencephalography (EEG), reflect a combination of TMS-induced cortical activity and multi-sensory responses to TMS. The aud...
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Article
Covid-19: a call for mobilizing geriatric expertise
Covid-19 is a true gerontological pandemic, with frailty, multimorbidity and geriatric syndromes being of great importance.
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Article
Open AccessPlasma and cerebrospinal fluid inflammation and the blood-brain barrier in older surgical patients: the Role of Inflammation after Surgery for Elders (RISE) study
Our understanding of the relationship between plasma and cerebrospinal fluid (CSF) remains limited, which poses an obstacle to the identification of blood-based markers of neuroinflammatory disorders. To bette...
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Article
Creating an anti-ageist healthcare system to improve care for our current and future selves
COVID-19 has highlighted pervasive ageism and the interconnectedness of individuals and societies. This Comment discusses how creating an anti-ageist healthcare system will improve health outcomes for our curr...
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Article
Open AccessTargeted metabolomics analysis of postoperative delirium
Postoperative delirium is the most common complication among older adults undergoing major surgery. The pathophysiology of delirium is poorly understood, and no blood-based, predictive markers are available. W...
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Article
Open AccessProcess of implementing and delivering the Prevention of Delirium system of care: a mixed method preliminary study
Delirium is a frequent complication of hospital admission among older people. Multicomponent interventions which can reduce incident delirium by ≈one-third are recommended by the National Institute of Health a...
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Article
Use of an expert panel to identify domains and indicators of delirium severity
Our purpose was to create a content domain framework for delirium severity to inform item development for a new instrument to measure delirium severity.
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Article
Open AccessUse of the confusion assessment method in multicentre delirium trials: training and standardisation
Delirium occurs commonly in older adults and is associated with adverse outcomes. Multicentre clinical trials evaluating interventions to prevent delirium are needed. The Confusion Assessment Method (CAM) is a...
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Article
Open AccessHarmonization of delirium severity instruments: a comparison of the DRS-R-98, MDAS, and CAM-S using item response theory
This study aimed to describe the level of agreement of three commonly used delirium instruments: the Delirium Rating Scale-Revised-98 (DRS-R-98), Memorial Delirium Assessment Scale (MDAS), and Confusion Assess...
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Article
Open AccessCorrection for retest effects across repeated measures of cognitive functioning: a longitudinal cohort study of postoperative delirium
Few studies have compared methods to correct for retest effects or practice effects in settings where an acute event could influence test performance, such as major surgery. Our goal in this study was to evalu...
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Article
Open AccessMethodologic considerations in the design and analysis of nested case-control studies: association between cytokines and postoperative delirium
The nested case-control study (NCC) design within a prospective cohort study is used when outcome data are available for all subjects, but the exposure of interest has not been collected, and is difficult or p...
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Article
Open AccessHELP! Problems in executing a pragmatic, randomized, stepped wedge trial on the Hospital Elder Life Program to prevent delirium in older patients
A pragmatic, stepped wedge trial design can be an appealing design to evaluate complex interventions in real-life settings. However, there are certain pitfalls that need to be considered. This paper reports on...
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Article
Open AccessCHERISH (collaboration for hospitalised elders reducing the impact of stays in hospital): protocol for a multi-site improvement program to reduce geriatric syndromes in older inpatients
Older inpatients are at risk of hospital-associated geriatric syndromes including delirium, functional decline, incontinence, falls and pressure injuries. These contribute to longer hospital stays, loss of ind...
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Article
Open AccessPrevention of delirium (POD) for older people in hospital: study protocol for a randomised controlled feasibility trial
Delirium is the most frequent complication among older people following hospitalisation. Delirium may be prevented in about one-third of patients using a multicomponent intervention. However, in the United Kin...
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Article
Open AccessConcordance between DSM-IV and DSM-5 criteria for delirium diagnosis in a pooled database of 768 prospectively evaluated patients using the delirium rating scale-revised-98
The Diagnostic and Statistical Manual fifth edition (DSM-5) provides new criteria for delirium diagnosis. We examined delirium diagnosis using these new criteria compared with the Diagnostic and Statistical Manua...
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Article
Open AccessDevelo** and implementing an integrated delirium prevention system of care: a theory driven, participatory research study
Delirium is a common complication for older people in hospital. Evidence suggests that delirium incidence in hospital may be reduced by about a third through a multi-component intervention targeted at known mo...
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Article
Open AccessDesign and methods of the Hospital Elder Life Program (HELP), a multicomponent targeted intervention to prevent delirium in hospitalized older patients: efficacy and cost-effectiveness in Dutch health care
The Hospital Elder Life Program (HELP) has been shown to be highly efficient and (cost-)effective in reducing delirium incidence in the USA. HELP provides multicomponent protocols targeted at specific risk fac...
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Article
Open AccessSelecting optimal screening items for delirium: an application of item response theory
Delirium (acute confusion), is a common, morbid, and costly complication of acute illness in older adults. Yet, researchers and clinicians lack short, efficient, and sensitive case identification tools for del...
