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Article
Open AccessCircuit analysis reveals a neural pathway for light avoidance in Drosophila larvae
Understanding how neural circuits underlie behaviour is challenging even in the connectome era because it requires a combination of anatomical and functional analyses. This is exemplified in the circuit underl...
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Article
Open AccessPredicting RNA hyper-editing with a novel tool when unambiguous alignment is impossible
Repetitive elements are now known to have relevant cellular functions, including self-complementary sequences that form double stranded (ds) RNA. There are numerous pathways that determine the fate of endogeno...
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Protocol
Genome-Wide Analysis of A-to-I RNA Editing
Adenosine (A)-to-inosine (I) RNA editing is a fundamental posttranscriptional modification that ensures the deamination of A-to-I in double-stranded (ds) RNA molecules. Intriguingly, the A-to-I RNA editing sys...
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Article
Open AccessDynamic response of RNA editing to temperature in Drosophila
Adenosine-to-inosine RNA editing is a highly conserved process that post-transcriptionally modifies mRNA, generating proteomic diversity, particularly within the nervous system of metazoans. Transcripts encodi...
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Article
Open AccessIdentification of evolutionarily meaningful information within the mammalian RNA editing landscape
A large comparative genomic sequence study has determined the extent of conservation between RNA editing sites within the mammalian evolutionary tree.
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Article
RNA editing regulates transposon-mediated heterochromatic gene silencing
Heterochromatin formation drives epigenetic mechanisms associated with silenced gene expression. Repressive heterochromatin is established through the RNA interference pathway, triggered by double-stranded RNA...
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Article
Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila
The accurate and thorough genome-wide detection of A-to-I editing has proven technically challenging. Using a combination of computational prediction and experimental validation, the authors report ~3,500 high...
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Article
The ADAR protein family
Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional process by which adenosines are selectively converted to inosines in double-stranded RNA (dsRNA) substrates. A highly conserved group of enzy...
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Article
Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila
Auto-regulatory feedback loops are a common molecular strategy used to optimize protein function. In Drosophila, many messenger RNAs involved in neuro-transmission are re-coded at the RNA level by the RNA-editing...
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Article
Visualizing adenosine-to-inosine RNA editing in the Drosophila nervous system
Adenosine-to-inosine RNA editing modifies expressed sequences and enhances functional protein diversity. The authors report an in vivo fluorescent reporter that provides a readout of adenosine deaminase RNA-editi...
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Article
Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein
Loss of FMR1 gene function results in fragile X syndrome. Here, the authors demonstrate that the Drosophila fragile X homolog dFMR1 is involved in the RNA editing pathway via interaction with the enzyme dADAR and...
