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Open AccessDifferential acute impact of therapeutically effective and overdose concentrations of lithium on human neuronal single cell and network function
Lithium salts are used as mood-balancing medication prescribed to patients suffering from neuropsychiatric disorders, such as bipolar disorder and major depressive disorder. Lithium salts cross the blood-brain...
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Article
Open AccessIn vitro neuronal network activity as a new functional diagnostic system to detect effects of Cerebrospinal fluid from autoimmune encephalitis patients
The intent of this study was to investigate if cerebrospinal fluid (CSF) from autoimmune encephalitis (AE) patients regulates in vitro neuronal network activity differentially to healthy human control CSF (hCSF)....
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Article
Open AccessFreshly frozen E18 rat cortical cells can generate functional neural networks after standard cryopreservation and thawing procedures
Primary dissociated brain tissue from rodents is widely used in a variety of different scientific methods to investigate cellular processes in vitro. Often, for this purpose cell cultures need to be generated ...
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Article
Open AccessBalanced splicing at the Tat-specific HIV-1 3′ss A3 is critical for HIV-1 replication
The viral regulatory protein Tat is essential for establishing a productive transcription from the 5′-LTR promoter during the early phase of viral gene expression. Formation of the Tat-encoding mRNAs requires ...
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Article
Open AccessHEXploring of the HIV-1 genome allows landsca** of new potential splicing regulatory elements
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Open AccessNiche-dependent development of functional neuronal networks from embryonic stem cell-derived neural populations
The present work was performed to investigate the ability of two different embryonic stem (ES) cell-derived neural precursor populations to generate functional neuronal networks in vitro. The first ES cell-derive...
