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Open AccessMST1 mediates doxorubicin-induced cardiomyopathy by SIRT3 downregulation
Heart failure is a major side effect of doxorubicin (DOX) treatment in patients with cancer. However, the mechanisms underlying the development of DOX-induced heart failure need to be addressed. This study aim...
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Article
Open AccessPolymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension
A dysfunction of NADH dehydrogenase, the mitochondrial Complex I (CI), associated with the development of left ventricular hypertrophy (LVH) in previous experimental studies. A deficiency of Ndufc2 (subunit of...
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Article
Open AccessAtrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure
Mitochondrial dysfunction, causing increased reactive oxygen species (ROS) production, is a molecular feature of heart failure (HF). A defective antioxidant response and mitophagic flux were reported in circul...
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Article
Elabela Peptide: A New Player in Hypertension and Vascular Damage
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Natriuretic Peptides in the Progression to Heart Failure in Hypertensive Patients
The natriuretic peptide (NPs) family includes three well-characterized hormones, namely, atrial natriuretic peptides (ANPs), brain natriuretic peptides (BNPs), and C-type natriuretic peptides (CNPs), all of wh...
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Article
Role of DAMPs and of Leukocytes Infiltration in Ischemic Stroke: Insights from Animal Models and Translation to the Human Disease
Stroke is a leading cause of death and disability worldwide. Several mechanisms are involved in the pathogenesis of ischemic stroke (IS). The contributory role of the inflammatory and immunity processes was de...
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Open AccessThe impact of autophagy modulation on phenotype and survival of cardiac stromal cells under metabolic stress
Cardiac stromal cells (CSCs) embrace multiple phenotypes and are a contributory factor in tissue homeostasis and repair. They can be exploited as therapeutic mediators against cardiac fibrosis and remodeling, ...
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Article
The Natriuretic Peptides for Hypertension Treatment
Hypertension is a common pathological condition predisposing to a higher occurrence of cardiovascular diseases and events. Unfortunately, treatment of hypertension is still suboptimal worldwide. More efforts a...
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Article
Relevance of stromal interaction molecule 1 (STIM1) in experimental and human stroke
Stroke represents a main cause of death and permanent disability worldwide. In the attempt to develop targeted preventive and therapeutic strategies, several efforts were performed over the last decades to ide...
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Targeting Cyclic Guanylate Monophosphate in Resistant Hypertension and Heart Failure: Are Sacubitril/Valsartan and Vericiguat Synergistic and Effective in Both Conditions?
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Article
Open AccessAn interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation
The mitochondrial uncoupling protein 2 (UCP2) plays a protective function in the vascular disease of both animal models and humans. UCP2 downregulation upon high-salt feeding favors vascular dysfunction in kno...
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Article
Epigenetic control of natriuretic peptides: implications for health and disease
The natriuretic peptides (NPs) family, including a class of hormones and their receptors, is largely known for its beneficial effects within the cardiovascular system to preserve regular functions and health. ...
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Article
Recommendations for Cardiovascular Prevention During the Sars-Cov-2 Pandemic: An Executive Document by the Board of the Italian Society of Cardiovascular Prevention
In 2020, the Sars-Cov-2 pandemic is causing a huge and dramatic impact on healthcare systems worldwide. During this emergency, fragile patients suffering from other comorbidities, especially patients susceptib...
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Article
Mitochondrial complex I deficiency and cardiovascular diseases: current evidence and future directions
Compelling evidence demonstrates the emerging role of mitochondrial complex I deficiency in the onset and development of cardiovascular diseases (CVDs). In particular, defects in single subunits of mitochondri...
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Chapter
Natriuretic Peptides
The cardiac natriuretic peptides (NPs) family comprises three main peptides (ANP, BNP and CNP) which are provided with properties relevant for cardiovascular and fluid homeostasis. They produce their cardiovas...
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Article
Executive Summary of the 2018 Joint Consensus Document on Cardiovascular Disease Prevention in Italy
Cardiovascular diseases (CVDs) are the leading cause of death, disability and hospitalization in Italy. Primary prevention strategies are able to prevent clinically evident CVDs, mostly by early identifying as...
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Article
Cellular and subcellular localization of uncoupling protein 2 in the human kidney
The uncoupling protein-2 (UCP2) is an anion transporter that plays a key role in the control of intracellular oxidative stress. In animal models UCP2 downregulation has several pathological sequelae, particula...
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Article
T2238C Atrial Natriuretic Peptide Gene Variant and the Response to Antiplatelet Therapy in Stable Ischemic Heart Disease Patients
The T2238C variant of the ANP gene is associated with higher risk of major cardiovascular events. The purpose of this study is to investigate if this polymorphism influences the response to antiplatelet agents...
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Open AccessC2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP
Subjects carrying the C2238 variant of the atrial natriuretic peptide (ANP) gene have a higher occurrence of stroke and acute coronary syndrome, suggesting an increased predisposition to acute thrombotic event...
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Article
Open AccessReduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat
UCP2 maps nearby the lod score peak of STR1-stroke QTL in the SHRSP rat strain. We explored the potential contribution of UCP2 to the high-salt diet (JD)-dependent increased stroke susceptibility of SHRSP. Male S...
