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Article
Open AccessThe impact of autophagy modulation on phenotype and survival of cardiac stromal cells under metabolic stress
Cardiac stromal cells (CSCs) embrace multiple phenotypes and are a contributory factor in tissue homeostasis and repair. They can be exploited as therapeutic mediators against cardiac fibrosis and remodeling, ...
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Article
On the Road to Regeneration: “Tools” and “Routes” Towards Efficient Cardiac Cell Therapy for Ischemic Cardiomyopathy
Cardiac regenerative medicine is a field bridging together biotechnology and surgical science. In this review, we present the explored surgical roads to cell delivery and the known effects of each delivery met...
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Article
Open AccessPlatelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful ...
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Article
The Biological Mechanisms of Action of Cardiac Progenitor Cell Therapy
Cell therapy for cardiovascular diseases is regarded as a rapidly growing field within regenerative medicine. Different cellular populations enriched for cardiac progenitor cells (CPCs), or derivate a-cellular...
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Article
MicroRNA-101 expression is associated with JAK2V617F activity and regulates JAK2/STAT5 signaling
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Article
Open AccessΒ-blockers treatment of cardiac surgery patients enhances isolation and improves phenotype of cardiosphere-derived cells
Β-blockers (BB) are a primary treatment for chronic heart disease (CHD), resulting in prognostic and symptomatic benefits. Cardiac cell therapy represents a promising regenerative treatment and, for autologous...
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Article
Primary microRNA transcripts are processed co-transcriptionally
MicroRNAs are processed by Drosha, and previous data had suggested that this occurred soon after transcription. Following Drosha recruitment and using nuclear run-on technology, data now indicate that miRNAs b...
