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  1. Article

    Open Access

    TWIST1 activates cancer stem cell marker genes to promote epithelial-mesenchymal transition and tumorigenesis in esophageal squamous cell carcinoma

    Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers worldwide. Overexpression of EMT master transcription factors can promote differentiated cells to undergo cancer reprogramming processe...

    Sima Ardalan Khales, Sina Mozaffari-Jovin, Dirk Geerts… in BMC Cancer (2022)

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    Article

    MAML1 promotes ESCC aggressiveness through upregulation of EMT marker TWIST1

    Mastermind-like 1 (MAML1) is the main transcriptional co-activator of Notch signaling pathway. It plays essential roles in several pathways including MEF2C, p53, Nf-кB and Wnt/β-catenin. TWIST1 is known as a r...

    Mohammad Mahdi Forghanifard, Shirin Azaraz… in Molecular Biology Reports (2020)

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    Article

    Predicting the Correlation of EZH2 and Cancer Stem Cell Markers in Esophageal Squamous Cell Carcinoma

    Enhancer of zeste homolog 2 (EZH2), a stemness factor, plays roles in regulation of cell differentiation and embryonic development as well as cancer progression. Deregulation of EZH2 in cancers is correlated w...

    GholamReza Karami Madani, Abolfazl Rad, Mehdi Molavi… in Journal of Gastrointestinal Cancer (2018)

  4. No Access

    Article

    Negative Regulatory Role of TWIST1 on SNAIL Gene Expression

    Epithelial-mesenchymal transition (EMT) is crucial for specific morphogenetic movements during embryonic development as well as pathological processes of tumor cell invasion and metastasis. TWIST and SNAIL pla...

    Mohammad Mahdi Forghanifard, Sima Ardalan Khales… in Pathology & Oncology Research (2017)

  5. No Access

    Article

    SALL4 as a new biomarker for early colorectal cancers

    Colorectal cancer (CRC) is one of the most common causes of cancer-related death worldwide, and there is an urgent need to identify critical diagnostic and prognostic factors for early detection of the disease...

    Sima Ardalan Khales… in Journal of Cancer Research and Clinical On… (2015)

  6. No Access

    Article

    Stemness state regulators SALL4 and SOX2 are involved in progression and invasiveness of esophageal squamous cell carcinoma

    Cancer stem cells, as a subgroup of tumor cells, resemble critical properties of embryonic stem cells (ESCs) such as self-renewal and maintenance of stemness state. SALL4 and SOX2 are two main transcription fact...

    Mohammad Mahdi Forghanifard, Sima Ardalan Khales… in Medical Oncology (2014)