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Article
Open AccessMEIS1 promotes expression of stem cell markers in esophageal squamous cell carcinoma
MEIS1 (Myeloid ecotropic viral integration site 1) as a homeobox (HOX) transcription factor plays regulatory roles in a variety of cellular processes including development, differentiation, survival, apoptosis...
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Article
Lycosin-II Suppresses the Growth of Tumor Cells and Kills them Through Membrane Disruption and Apoptosis Induction
Recently, there has been a growing interest in the discovery of novel chemotherapeutic agents that have fewer side effects and are less likely to develop resistance. This study was conducted to examine the ant...
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Article
Open AccessEffects of glucosamine against morphine-induced antinociceptive tolerance and dependence in mice
The most important limitations of morphine in pain therapy are its tolerance and dependence. In this study, we evaluated the protective effect of glucosamine against morphine-induced tolerance and dependence i...
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Article
Predicting the Correlation of EZH2 and Cancer Stem Cell Markers in Esophageal Squamous Cell Carcinoma
Enhancer of zeste homolog 2 (EZH2), a stemness factor, plays roles in regulation of cell differentiation and embryonic development as well as cancer progression. Deregulation of EZH2 in cancers is correlated w...
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Article
Open AccessExpanding the clinical phenotype of IARS2-related mitochondrial disease
IARS2 encodes a mitochondrial isoleucyl-tRNA synthetase, a highly conserved nuclear-encoded enzyme required for the charging of tRNAs with their cognate amino acid for translation. Recently, pathogenic IARS2 vari...
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Article
MPZL2 is a novel gene associated with autosomal recessive nonsyndromic moderate hearing loss
While recent studies have revealed a substantial portion of the genes underlying human hearing loss, the extensive genetic landscape has not been completely explored. Here, we report a loss-of-function variant...
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Article
Correction to: Metoclopramide role in preventing ileus after cesarean, a clinical trial
The original publication of this paper contains an error.
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Article
Crosstalk between SHH and stemness state signaling pathways in esophageal squamous cell carcinoma
The expression of GLI1 as a downstream gene of sonic hedgehog (Hh) pathway, studied in a variety of cancers including esophageal squamous cell carcinoma (ESCC). However, the interaction of Hh with other develo...
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Article
Negative Regulatory Role of TWIST1 on SNAIL Gene Expression
Epithelial-mesenchymal transition (EMT) is crucial for specific morphogenetic movements during embryonic development as well as pathological processes of tumor cell invasion and metastasis. TWIST and SNAIL pla...
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Article
Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma
Homeobox (HOX) transcription factors are critical regulators of cell fate, stem cell functions, and gastrointestinal development. They require three-amino acid loop extension (TALE) homeodomain proteins such a...
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Article
Predicting the molecular role of MEIS1 in esophageal squamous cell carcinoma
The three amino acid loop extension (TALE) class myeloid ecotropic viral integration site 1 (MEIS1) homeobox gene is known to play a crucial role in normal and tumor development. In contrast with its well-describ...
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Article
Metoclopramide role in preventing ileus after cesarean, a clinical trial
Ileus is a common event following cesarean section. Early post-cesarean recovery is very important not only for the mother but also for the baby who is dependent on breastfeeding. This article aims to demonstr...
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Article
Stemness state regulators SALL4 and SOX2 are involved in progression and invasiveness of esophageal squamous cell carcinoma
Cancer stem cells, as a subgroup of tumor cells, resemble critical properties of embryonic stem cells (ESCs) such as self-renewal and maintenance of stemness state. SALL4 and SOX2 are two main transcription fact...
