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Article
Open AccessHigh-throughput metabolomics identifies new biomarkers for cervical cancer
Cervical cancer (CC) is a danger to women’s health, especially in many develo** countries. Metabolomics can make the connection between genotypes and phenotypes. It provides a wide spectrum profile of biolog...
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Article
Electrochemical immunosensor nanoarchitectonics with the Ag-rGO nanocomposites for the detection of receptor-binding domain of SARS-CoV-2 spike protein
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a grave threat to human life and health, it is essential to develop an efficient and sensitive detection method to identify infected in...
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Article
Open AccessCHIP promotes the activation of NF-κB signaling through enhancing the K63-linked ubiquitination of TAK1
Transcriptional factor nuclear factor κB (NF-κB) can be activated by various intracellular or extracellular stimuli and its dysregulation leads to pathological conditions, such as neurodegenerative disorders, ...
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Article
Red fluorescent nanoprobe based on Ag@Au nanoparticles and graphene quantum dots for H2O2 determination and living cell imaging
A sensitive and turn-on fluorescence nanoprobe based on core-shell Ag@Au nanoparticles (Ag@AuNPs) as a fluorescence receptor and red emissive graphene quantum dots (GQDs) as a donor was fabricated. They were c...
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Article
Open AccessCHIP promotes Wnt signaling and regulates Arc stability by recruiting and polyubiquitinating LEF1 or Arc
The carboxyl terminus of Hsc70-interacting protein (CHIP), an E3 ubiquitin ligase, participates in many cellular processes such as protein degradation, trafficking, autophagy, apoptosis, and multiple signaling...
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Chapter and Conference Paper
A Sequence-Based Antibody Paratope Prediction Model Through Combing Local-Global Information and Partner Features
Antibodies are proteins which play a vital role in the immune system by recognizing and neutralizing antigens. The region on the antibody binding to an antigen, known as paratope, mediates antibody-antigen int...
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Article
Open AccessA Hierarchical Mechanism of RIG-I Ubiquitination Provides Sensitivity, Robustness and Synergy in Antiviral Immune Responses
RIG-I is an essential receptor in the initiation of the type I interferon (IFN) signaling pathway upon viral infection. Although K63-linked ubiquitination plays an important role in RIG-I activation, the optim...
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Article
MicroRNA-26a Promotes Regulatory T cells and Suppresses Autoimmune Diabetes in Mice
Type-1 diabetes (TID) is an autoimmune disease in which the body’s own immune cells attack islet β cells, the cells in the pancreas that produce and release the hormone insulin. Mir-26a has been reported to pl...
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Article
Open AccessPhase Diagram and High-Temperature Superconductivity of Compressed Selenium Hydrides
Recent discovery of high-temperature superconductivity (Tc = 190 K) in sulfur hydrides at megabar pressures breaks the traditional belief on the Tc limit of 40 K for conventional superconductors and opens up the ...
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Article
Open AccessHypervalent Iodine with Linear Chain at High Pressure
Iodine is an element of fascinating chemical complexity and numerous hypervalent iodine compounds reveal vital value of applications in organic synthesis. Investigation of the synthesis and application of new ...
