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Article
DNA-functionalized artificial mechanoreceptor for de novo force-responsive signaling
Synthetic signaling receptors enable programmable cellular responses coupling with customized inputs. However, engineering a designer force-sensing receptor to rewire mechanotransduction remains largely unexpl...
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Article
Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli
Liver sinusoidal endothelial cells (LSECs) are the gatekeeper of liver to maintain hepatic homeostasis. They are formed into the highly specialized endothelium between vascular lumen and the space of Disse and...
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Article
Flow field analyses of a porous membrane-separated, double-layered microfluidic chip for cell co-culture
Organs-on-chips composed of a porous membrane-separated, double-layered channels are used widely in elucidating the effects of cell co-culture and flow shear on biological functions. While the diversity of cha...
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Article
Open AccessGlobal map** of live cell mechanical features using PeakForce QNM AFM
Atomic force microscopy (AFM) has been widely used to acquire surface topography upon different scanning modes and to quantify mechanical properties of a cell using single-point ramp force mode. However, these...
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Article
Mechanochemical modeling of neutrophil migration based on four signaling layers, integrin dynamics, and substrate stiffness
Directional neutrophil migration during human immune responses is a highly coordinated process regulated by both biochemical and biomechanical environments. In this paper, we developed an integrative mathemati...
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Article
Reply to ‘Early sha** of a leaf’
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Article
Theoretical modeling of mechanical homeostasis of a mammalian cell under gravity-directed vector
Translocation of dense nucleus along gravity vector initiates mechanical remodeling of a eukaryotic cell. In our previous experiments, we quantified the impact of gravity vector on cell remodeling by placing a...
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Article
Mechanical regulation of organ asymmetry in leaves
How appendages, such as plant leaves or animal limbs, develop asymmetric shapes remains a fundamental question in biology. Although ongoing research has revealed the genetic regulation of organ pattern formati...
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Article
Flow dynamics analyses of pathophysiological liver lobules using porous media theory
Blood flow inside the liver plays a key role in hepatic functions, and abnormal hemodynamics are highly correlated with liver diseases. To date, the flow field in an elementary building block of the organ, the...
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Article
Open AccessStructural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir Channels
The effect of the conserved Leu/Ile site in the CD loop on the gating dynamics of Kir channels and corresponding micro-structural mechanism remains unclear. Molecular dynamics simulations were performed to inv...
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Article
Open AccessIdentification of the Conformational transition pathway in PIP2 Opening Kir Channels
The gating of Kir channels depends critically on phosphatidylinositol 4,5-bisphosphate (PIP2), but the detailed mechanism by which PIP2 regulates Kir channels remains obscure. Here, we performed a series of Targe...
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Article
Mechanokinetics of receptor–ligand interactions in cell adhesion
Receptor–ligand interactions in blood flow are crucial to initiate such biological processes as inflammatory cascade, platelet thrombosis, as well as tumor metastasis. To mediate cell adhesion, the interacting...
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Chapter and Conference Paper
Distinct Kinetics Features of LFA-1 and Mac-1 in Neutrophil Activation
LFA-1 and Mac-1, two β 2 integrin members constitutively expressed on neutrophils, mediate leukocyte recruitment cascade by binding to the same ligand of ICAM-1. The slow rolling and firm adhesion o...
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Article
Probe stiffness regulates receptor-ligand bond lifetime under force
Receptor-ligand bond dissociation under applied force is crucial to elucidate its biological functionality when the molecular bond is usually connected to a mechanical probe. While the impact of probe stiffness,
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Article
Forced extension of P-selectin construct using steered molecular dynamics
P-selectin, a 70-nm-long cellular adhesive molecule, possesses elastic and extensible properties when neutrophils roll over the activated endotheliam of blood vessel in inflammatory reaction. Transient formati...
