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Article
Open AccessToxic Effects of Size-tunable Gold Nanoparticles on Caenorhabditis elegans Development and Gene Regulation
We utilized size-tunable gold nanoparticles (Au NPs) to investigate the toxicogenomic responses of the model organism Caenorhabditis elegans. We demonstrated that the nematode C. elegans can uptake Au NPs coated ...
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Article
Open AccessGold nanoparticles as multimodality imaging agents for brain gliomas
Nanoparticles can be used for targeted drug delivery, in particular for brain cancer therapy. However, this requires a detailed analysis of nanoparticles from the associated microvasculature to the tumor, not ...
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Article
Open AccessX-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells
We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such...
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Article
Open AccessGold nanoparticles as high-resolution X-ray imaging contrast agents for the analysis of tumor-related micro-vasculature
Angiogenesis is widely investigated in conjunction with cancer development, in particular because of the possibility of early stage detection and of new therapeutic strategies. However, such studies are negati...
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Article
Imaging the cellular uptake of tiopronin-modified gold nanoparticles
Well-dispersed gold nanoparticles (NP) coated with tiopronin were synthesized by X-ray irradiation without reducing agents. High-resolution transmission electron microscopy shows that the average core diameter...
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Article
Open AccessQuantitative analysis of nanoparticle internalization in mammalian cells by high resolution X-ray microscopy
Quantitative analysis of nanoparticle uptake at the cellular level is critical to nanomedicine procedures. In particular, it is required for a realistic evaluation of their effects. Unfortunately, quantitative...
