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Article
Author Correction: A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
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Article
Open AccessTau follows principal axes of functional and structural brain organization in Alzheimer’s disease
Alzheimer’s disease (AD) is a brain network disorder where pathological proteins accumulate through networks and drive cognitive decline. Yet, the role of network connectivity in facilitating this accumulation...
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Article
A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
The cortical patterning principle has been a long-standing question in neuroscience, yet how this translates to macroscale functional specialization in the human brain remains largely unknown. Here we examine ...
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Article
Open AccessAnterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in Grin2b-mutant mice
Sensory abnormalities are observed in ~90% of individuals with autism spectrum disorders (ASD), but the underlying mechanisms are poorly understood. GluN2B, an NMDA receptor subunit that regulates long-term de...
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Article
Gradients of Brain Organization: Smooth Sailing from Methods Development to User Community
Multimodal neuroimaging grants a powerful in vivo window into the structure and function of the human brain. Recent methodological and conceptual advances have enabled investigations of the interplay between l...
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Article
Open AccessDiverging asymmetry of intrinsic functional organization in autism
Autism is a neurodevelopmental condition involving atypical sensory-perceptual functions together with language and socio-cognitive deficits. Previous work has reported subtle alterations in the asymmetry of b...
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Article
Open AccessConnectivity alterations in autism reflect functional idiosyncrasy
Autism spectrum disorder (ASD) is commonly understood as an alteration of brain networks, yet case-control analyses against typically-develo** controls (TD) have yielded inconsistent results. Here, we devise...
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Article
Open AccessDifferences in subcortico-cortical interactions identified from connectome and microcircuit models in autism
The pathophysiology of autism has been suggested to involve a combination of both macroscale connectome miswiring and microcircuit anomalies. Here, we combine connectome-wide manifold learning with biophysical...
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Article
Open AccessBrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets
Understanding how cognitive functions emerge from brain structure depends on quantifying how discrete regions are integrated within the broader cortical landscape. Recent work established that macroscale brain...
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Article
Open AccessAtypical functional connectome hierarchy in autism
One paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-cognitive processing. Here, we examined whether these phenotypical patterns may relate to an overarching system-level im...
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Chapter and Conference Paper
Deep Convolutional Networks for Automated Detection of Epileptogenic Brain Malformations
Focal cortical dysplasia (FCD) is a prevalent surgically-amenable epileptogenic malformation of cortical development. On MRI, FCD typically presents with cortical thickening, hyperintensity, and blurring of th...
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Chapter and Conference Paper
Automated Detection of Epileptogenic Cortical Malformations Using Multimodal MRI
Focal cortical dysplasia (FCD), a malformation of cortical development, is a frequent cause of drug-resistant epilepsy. This surgically-amenable lesion is histologically characterized by cortical dyslaminatio...
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Chapter and Conference Paper
Connectome-Based Pattern Learning Predicts Histology and Surgical Outcome of Epileptogenic Malformations of Cortical Development
Focal cortical dysplasia (FCD) type II, a surgically amenable epileptogenic malformation, is characterized by intracortical dyslamination and dysmorphic neurons, either in isolation (IIA) or together with ball...
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Article
Open AccessMulti-contrast submillimetric 3 Tesla hippocampal subfield segmentation protocol and dataset
The hippocampus is composed of distinct anatomical subregions that participate in multiple cognitive processes and are differentially affected in prevalent neurological and psychiatric conditions. Advances in ...
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Chapter and Conference Paper
MRI-Based Lesion Profiling of Epileptogenic Cortical Malformations
Focal cortical dysplasia (FCD), a malformation of cortical development, is a frequent cause of drug-resistant epilepsy. This lesion is histologically classified into Type-IIA (dyslamination, dysmorphic neurons...
