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Open AccessGenomic dissection and mutation-specific target discovery for breast cancer PIK3CA hotspot mutations
Recent advancements in high-throughput genomics and targeted therapies have provided tremendous potential to identify and therapeutically target distinct mutations associated with cancers. However, to date the...
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Open AccessAuthor Correction: scCircle-seq unveils the diversity and complexity of extrachromosomal circular DNAs in single cells
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Open AccessscCircle-seq unveils the diversity and complexity of extrachromosomal circular DNAs in single cells
Extrachromosomal circular DNAs (eccDNAs) have emerged as important intra-cellular mobile genetic elements that affect gene copy number and exert in trans regulatory roles within the cell nucleus. Here, we desc...
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Open AccessFatty acid synthase as a new therapeutic target for HER2-positive gastric cancer
Trastuzumab is an HER2-specific agent approved as the gold-standard therapy for advanced HER2-positive (HER2+) gastric cancer (GC), but the high rate and rapid appearance of resistance limit its clinical effic...
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Open AccessIntegrative genomic and transcriptomic analyses illuminate the ontology of HER2-low breast carcinomas
The “HER2-low” nomenclature identifies breast carcinomas (BCs) displaying a HER2 score of 1+/2+ in immunohistochemistry and lacking ERBB2 amplification. Whether HER2-low BCs (HLBCs) constitute a distinct entity i...
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Open AccessClustered protocadherins methylation alterations in cancer
Clustered protocadherins (PCDHs) map in tandem at human chromosome 5q31 and comprise three multi-genes clusters: α-, β- and γ-PCDH. The expression of this cluster consists of a complex mechanism involving DNA hub...
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Correction: Corrigendum: Stromal contribution to the colorectal cancer transcriptome
Nat. Genet. 47, 312–319 (2015); published online 23 February 2015; corrected after print 29 August 2016 In the version of this article initially published, an affiliation for author Zsolt Fekete was incorrectl...
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Stromal contribution to the colorectal cancer transcriptome
Claudio Isella and colleagues report an analysis of colorectal cancer (CRC) gene expression data from patient-derived xenografts, which they use to reconcile three commonly used CRC classification systems. The...
