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Article
Open AccessSelective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
Stromal content heavily impacts the transcriptional classification of colorectal cancer (CRC), with clinical and biological implications. Lineage-dependent stromal transcriptional components could therefore do...
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Article
Correction: Corrigendum: Stromal contribution to the colorectal cancer transcriptome
Nat. Genet. 47, 312–319 (2015); published online 23 February 2015; corrected after print 29 August 2016 In the version of this article initially published, an affiliation for author Zsolt Fekete was incorrectl...
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Article
Open AccessMicroRNA–mRNA interactions underlying colorectal cancer molecular subtypes
Colorectal cancer (CRC) transcriptional subtypes have been recently identified by gene expression profiling. Here we describe an analytical pipeline, microRNA master regulator analysis (MMRA), developed to sea...
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Article
Open AccessA diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells
We developed a selectable marker rendering human cells resistant to Diphtheria Toxin (DT). The marker (DTR) consists of a primary microRNA sequence engineered to downregulate the ubiquitous DPH2 gene, a key enzym...
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Article
Stromal contribution to the colorectal cancer transcriptome
Claudio Isella and colleagues report an analysis of colorectal cancer (CRC) gene expression data from patient-derived xenografts, which they use to reconcile three commonly used CRC classification systems. The...
