6 Result(s)
within
Jean-Pierre Y Scheerlinck
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Article
Open AccessInvestigating immune responses to parasites using transgenesis
Parasites comprise diverse and complex organisms, which substantially impact human and animal health. Most parasites have complex life-cycles, and by virtue of co-evolution have developed multifaceted, often l...
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Article
Open AccessTranscriptional analysis identifies key genes involved in metabolism, fibrosis/tissue repair and the immune response against Fasciola hepatica in sheep liver
Although fascioliasis has been relatively well studied, little is known about the molecular basis of this disease. This is particularly relevant, considering the very different response that sheep have to Fasciol...
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Article
Open AccessOmega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo
Schistosomiasis, one of the most important neglected tropical diseases worldwide, is caused by flatworms (blood flukes or schistosomes) that live in the bloodstream of humans. The hepatointestinal form of this...
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Article
Open AccessGenome and transcriptome of the porcine whipworm Trichuris suis
Aaron Jex and colleagues report whole-genome sequencing of adult male and female whipworm, Trichuris suis, from experimentally infected pigs. They also report stage-, sex- and tissue-specific transcriptomes and p...
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Article
White Matter Injury after Repeated Endotoxin Exposure in the Preterm Ovine Fetus
Intrauterine infection has been linked to neurologic injury in preterm infants. However, a reproducible model of white matter injury in the preterm fetus in a long gestation species that can be monitored in utero
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Article
Cloning and sequence comparison of sheep CD28 and CTLA-4
