-
Article
Evaluation of chitotriosidase as a biomarker for adipose tissue inflammation in overweight individuals and type 2 diabetic patients
Overweight and obesity can lead to adipose tissue inflammation, which causes insulin resistance and on the long-term type 2 diabetes mellitus (T2D). The inflammatory changes of obese-adipose tissue are charact...
-
Article
Open AccessAbstracts from the Food Allergy and Anaphylaxis Meeting 2016
-
Article
Metabolite profiling of small cerebrospinal fluid sample volumes with gas chromatography–mass spectrometry: application to a rat model of multiple sclerosis
Analysis of metabolites in biofluids by gas chromatography–mass spectrometry (GC–MS) after oximation and silylation is a key method in metabolomics. The GC–MS method was modified by a modified vial design and ...
-
Article
Open AccessFish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues
It is well established that dietary intake of n-3 fatty acids is associated with anti-inflammatory effects, and this has been linked to modulation of the oxylipin and endocannabinoid metabolomes. However, the ...
-
Article
Open AccessVisualization and identification of health space, based on personalized molecular phenotype and treatment response to relevant underlying biological processes
Being able to visualize multivariate biological treatment effects can be insightful. However the axes in visualizations are often solely defined by variation and thus have no biological meaning. This makes the...
-
Article
A Framework for Efficient Process Development Using Optimal Experimental Designs
The aim of this study was to develop and demonstrate a framework assuring efficient process development using fewer experiments than standard experimental designs.
-
Article
Open AccessAssessing the performance of statistical validation tools for megavariate metabolomics data
Statistical model validation tools such as cross-validation, jack-knifing model parameters and permutation tests are meant to obtain an objective assessment of the performance and stability of a statistical mo...
