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Article
Metabolite profiling of small cerebrospinal fluid sample volumes with gas chromatography–mass spectrometry: application to a rat model of multiple sclerosis
Analysis of metabolites in biofluids by gas chromatography–mass spectrometry (GC–MS) after oximation and silylation is a key method in metabolomics. The GC–MS method was modified by a modified vial design and ...
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Article
Open AccessPlasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status
We introduce the metabolomics and proteomics based Postprandial Challenge Test (PCT) to quantify the postprandial response of multiple metabolic processes in humans in a standardized manner. The PCT comprised ...
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Article
Open AccessImproving the analysis of designed studies by combining statistical modelling with study design information
In the fields of life sciences, so-called designed studies are used for studying complex biological systems. The data derived from these studies comply with a study design aimed at generating relevant informat...
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Article
Open AccessAssessing the performance of statistical validation tools for megavariate metabolomics data
Statistical model validation tools such as cross-validation, jack-knifing model parameters and permutation tests are meant to obtain an objective assessment of the performance and stability of a statistical mo...
