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Article
Safety and effectiveness of a somatropin biosimilar in children requiring growth hormone treatment: second analysis of the PATRO Children study Italian cohort
To investigate the long-term safety (primary endpoint) and effectiveness (secondary endpoint) of the somatropin biosimilar Omnitrope®.
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Article
Extreme hyperosmolarity and severe ketoacidosis in a child with type 1 diabetes mellitus at onset safely treated with current guidelines
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Article
Relationships between thyroid function and autoimmunity with metabolic derangement at the onset of type 1 diabetes: a cross-sectional and longitudinal study
Type 1 diabetes (T1DM) is an autoimmune disease often associated with thyroid abnormalities.
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Article
Growth hormone treatment of adolescents with growth hormone deficiency (GHD) during the transition period: results of a survey among adult and paediatric endocrinologists from Italy. Endorsed by SIEDP/ISPED, AME, SIE, SIMA
Treatment of adolescents with growth hormone deficiency (GHD) during the transition period is a controversial issue. This paper is a contribution from the Italian community of paediatric and adult endocrinolog...
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Article
Transition from pediatric to adult care. Eight years after the transition from pediatric to adult diabetes care: metabolic control, complications and associated diseases
Transition from pediatric to adult care is a critical process in the life of patients with diabetes.
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Article
Severe hypoglycemic episodes: A persistent threat for children with Type 1 diabetes mellitus and their families
Background: As lowering glycated hemoglobin (HbA1c) levels is still the main goal of insulin treatment, severe hypoglycemia (SH) remains a common experience in children with Type 1 diabetes melli...
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Article
Long-term auxological and pubertal outcome of patients with hereditary insulin-like growth factor-I deficiency (Laron and growth hormone-gene deletion syndrome) treated with recombinant human insulin-like growth factor-I
Background: GH-IGF-I axis is mainly involved in the complex process of somatic growth but emerging evidence suggests that it also influences hypothalamic-pituitary-gonadal (HPG) function....
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Article
Final height in a patient with Laron syndrome after long-term therapy with rhIGF-I and short-term therapy with LHRH-analogue and oxandrolone during puberty
Objective: To report our experience on long-term treatment with recombinant-human-IGF-I (rhIGF-I) of a female patient with Laron syndrome (mutation G223G in the GH receptor gene), who received short-term treat...
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Article
Effects of defective herpes simplex vectors expressing neurotrophic factors on the proliferation and differentiation of nervous cells in vivo
Neurotrophic factors (NTFs) are known to govern the processes involved in central nervous system cell proliferation and differentiation. Thus, they represent very attractive candidates for use in the study and...
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Article
Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice
Receptor antagonist and knockout studies have demonstrated that blockade of signalling via nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) has antidepressant-like effects in mice submitted to the forced ...
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Article
Replication-defective herpes simplex virus vectors for neurotrophic factor gene transfer in vitro and in vivo
We report here the construction and the use of two replication-defective herpes simplex virus vectors, SH FGF-2 and TH FGF-2, which efficiently transfer and express the cDNA for fibroblast-growth-factor-2 (FGF...
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Article
116 GROWTH FACTORS IN HUMAN FOETAL PLASMA DURING THE SECOND TRIMESTER OF GESTATION: “IN UTERO” STUDY
The role of growth factors in fetal development is not clear. Fetal blood was obtained from 61 fetuses aged 19-25 weeks during the course of funicolocentesis performed for: suspected thalassaemia, fetal malfor...
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Article
165 ADRENOCORTICAL INSUFFICIENCY ASSOCIATED WITH ACHALASIA AND ALACRINA: VARIABILITY OF CLINICAL FINDINGS IN TWO CASES
After the 4 patients reported by Allgrove in 1978, only few cases of the ACTH insensitivity, achalasia and alacrima syndrome have been described. Some clinical aspects of the disorder and its pathogenesis has ...
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Article
TREATMENT WITH CLONIDINE IN SUBJECTS WITH CONSTITUTIONAL GROWTH DELAY (CGO): A CONTROLLED DOUBLE-BLIND STUDY
In 1985, Pintor et al. reported that treatment with clonidine (CI), an α2-a-drenergic agonist, accelerates growth in children with growth disorders. In order to confirm or disprove this observation, we studied...
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Article
PREVALENCE OF COELIAC DISEASE IN TYPE 1 DIABETES MELLITUS: A STUDY PERFORMED VIA TESTS FOR ANTIGLIADIN ANTIBODIES
The association between diabetes mellitus and coeliac disease has been described a number of times. By using tests for antireticulin antibodies, Maki et al. found a greater prevalence of the disease in diabeti...
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Article
Somatomedin-C levels related to gestational age, birth weight and day of life
Capillary blood samples on filter paper were assayed by means of an RIA method (Kit Nichols Institute USA) from 1096 newborns divided into full term, preterm and small-for-date infants. The somatomedin-C (Sm-C...
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Article
44 GH, HPRL, ACTH, TSH AND SmC RESPONSE TO GH-RF IN CHILDREN WITH PITUITARY DWARFISM
20 prepubertal GH-deficient children (C.A. 4.88-17.75yrs) were studied; 15 patients had isolated GH-deficiency, 5 had multiple pituitary hormone deficiencies, such as GH-ACTH-TSH (1 case), GH-TSH (2 cases), GH...
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Article
45 SmC RESPONSE TO hGH AND GH-RF IN GH-RF-DEFICIENT CHILDREN
4 GH-RF deficient children (1 with isolated GH-deficiency, 2 with GH-TSH deficiencies, 1 with GH-TSH-ACTH-deficiencies) were administered s.c. hGH (after the previous hGH treatment had been discontinued 1 week...
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Article
Somatomedin-C in fullterm, preterm and small for date infants
Capillary blood samples on filter paper were assayed by means of a RIA method (kit Nichols Institute USA) from 1096 newborns divided into fullterm,preterm and small for date infants.Somatomedin-C (SmC) mean va...
