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Article
Increased large artery intima media thickness in adolescents with either classical or non-classical congenital adrenal hyperplasia
Background: Increased artery intima-media thickness (IMT) was found in adults with classical congenital adrenal hyperplasia (CAH). No data are available in patients with non-classical (NC) CAH. A...
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Article
A sequence variation in 3’UTR of CYP21A2 gene correlates with a mild form of congenital adrenal hyperplasia
Background: Congenital adrenal hyperplasia (CAH) is mainly caused by the deficiency of the 21-hydroxylase enzyme coded by the CYP21A2 gene. However, some alleles in the non-classical form (NC-CAH...
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Article
Prediction of response to growth hormone treatment in pre-pubertal children with growth hormone deficiency
Background: GH therapy response varies substantially among patients. Several models were developed to predict the efficacy of GH therapy in children. Aim: To evaluate the accuracy of a gr...
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Article
17β-Hydroxysteroid dehydrogenase-3 deficiency: From pregnancy to adolescence
Objective: Aim of this study is to report on basal clinical phenotype and follow up after diagnosis, of patients with 17β-hydroxysteroid-dehydrogenase type 3 (17β-HSD3) deficiency in Ital...
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Article
Hearing loss in Turner syndrome: Results of a multicentric study
The purpose of this article was to evaluate otological diseases in 173 patients (pts) with Turner syndrome (TS). Study design: One hundred and seventy-three pts, mean chronological age (CA) 12±6.2 yr. Patients we...
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Article
Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr)
The aim of this study is to extend to pre-school ages the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP)-2002 growth charts for height, weight and body mass index (BMI), to obtain charts (SIE...
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Article
Functional studies of two novel and two rare mutations in the 21-hydroxylase gene
Congenital adrenal hyperplasia (CAH) is most commonly due to 21-hydroxylase deficiency and presents with a wide spectrum of clinical manifestations, from prenatal virilization and salt-wasting in the neonatal ...
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Article
Low serum inhibin B levels as a marker of testicular damage after treatment for a childhood malignancy
The aim of this study was to evaluate the role of inhibin B and the determination of its concentration to diagnose testicular damage after treatment for a childhood malignancy. Thirty-seven males treated for ...
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Article
On the linguistic nature of cyberspace and virtual communities
This paper argues for a linguistic explanation of the nature of Virtual Communities. Virtual Communities develop and grow in electronic space. or ‘cyberspace’. Authors such as Benedikt Meyrowitz and Mitchell h...
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Article
Abnormal insulin response to glucose following treatment for Wilms' tumor in childhood
To determine whether β-cell function could be impaired by the treatment for Wilms' tumour (WT) in childhood, we investigated the insulin secretion of 44 survivors of WT (22 males) with a median off-treatment ...
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Article
Longitudinal growth and final height in long-term survivors of childhood leukaemia
Survival of children with acute lymphoblastic leukaemia (ALL) has increased considerably in recent years and data on the spontaneous growth and final height of these children are conflicting. Therefore, we ana...
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Article
What will be the adult height of coeliac patients?
We studied three groups of patient with coeliac disease: group 1=95 adult patients with gastro-intestinal symptoms diagnosed after reaching adult height, 41 of whom had had symptoms during childhood; group 2=2...
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Chapter
The WHO-ISFC study on pathobiological determinants of atherosclerosis in youth (PBDAY): a first morphometric approach to aortic lesions
One of the aims of the PBDAY Study (WHO-ISFC) is to examine, both in children and young adults, the arterial structural changes which may determine the development of atherosclerosis, especially in its early s...
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Article
136 TREATMENT OF PRECOCIOUS PUBERTY BY INIRANASAL D-SER (TBU)6 LHRHI – 9EA10(BUSERELIN
GnRH analogues afford effective, selective, reversible inhibition of pituitary gonadotropin secretion. We administered Buserelin (300 ug × 6/die) to 18 girls affected by precocious puberty, for 6-24 months (on...
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Article
115 EFFECT OF GONADECTOMY ON GROWTH FACTORS IN TESTICULAR FENINIZED CHILDREN
Sm-C increase during puberty or sex hormones treatment. Whether this increase is mediated by GH is still unclear. Children with testicular feminization submitted to gonadectomy provide a good model to assess t...
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Article
Differences in carbohydrate tolerance in Turner syndrome depending on age and karyotype
Carbohydrate homeostasis was evaluated in 47 girls with Turner syndrome and in 25 “short normal” girls by means of an oral glucose tolerance test. Of the Turner patients 34% showed an impaired glucose toleranc...
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Article
Haemorheologic and fibrinolytic evaluation in obese children and adolescents
The haemorheologic condition was evaluated in 43 obese children and 35 controls. In 18 of the obese children and in 21 controls the euglobulin lysis time (ELT) was also studied. Blood viscosity at 94.5 and at ...
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Article
EFFECT OF ESTROGEN-PROGESTOGEN TREATMENT ON CARBOHYDRATE TOLERANCE IN TURNER'S SYNDROME
Glucose tolerance was evaluated by means of an OGTT in 16 girls with Turner's syndrome submitted to estrogen-progestogen treatment (10 subjects 45, X, 1 X-mosaic and 5 X structural abnormalities). OGTT was per...
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Article
DIFFERENCES IN GLUCOSE TOLERANCE IN TURNER'S SYNDROME DEPENDING ON AGE
Carbohydrate homeostasis was evaluated in 41 Turner-syndrome (mean age 11.5±2.7, range 5-16yrs) and in 25 short normal girls (mean age 10.8±2.7, range 6-16 yrs) by means of DGTT. Impaired glucose tolerance was...
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Article
Somatomedin-C levels related to gestational age, birth weight and day of life
Capillary blood samples on filter paper were assayed by means of an RIA method (Kit Nichols Institute USA) from 1096 newborns divided into full term, preterm and small-for-date infants. The somatomedin-C (Sm-C...
