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Chapter and Conference Paper
A Smart System for Shock and Vibration Isolation of Sensitive Electronic Devices On-Board a Vehicle
The paper presents an innovative system for shock and vibration isolation of a set of racks on-board vehicles containing equipment sensitive to accelerations. The suspension system is composed of air springs s...
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Article
Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma
We identified a discrete number of microRNAs differentially expressed in benign or malignant mesothelial tissues. We focused on mir-145 whose levels were significantly downregulated in malignant mesothelial ti...
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Article
Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells
Mutant p53 proteins are expressed at high frequency in human tumors and are associated with poor clinical prognosis and resistance to chemotherapeutic treatments. Here we show that mutant p53 proteins downregu...
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Article
ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence
Werner syndrome (WS) results from dysfunction of the WRN protein, and is associated with premature aging and early death. Here we report that loss of WRN function elicits accumulation of the Yes-associated pro...
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Article
Open AccessmiR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer
Micro RNAs (miRs) are small non-coding RNAs aberrantly expressed in human tumors. Here, we aim to identify miRs whose deregulated expression leads to the activation of oncogenic pathways in human gastric cance...
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Article
SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells
Here we show that pemetrexed-treated mesothelioma cells undergo accelerated senescence. This is characterized by the secretion of proinflammatory and mitogenic cytokines, reminiscent of an SASP (senescence-ass...
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Article
MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function
p53 mutations have profound effects on non-small-cell lung cancer (NSCLC) resistance to chemotherapeutic treatments. Mutant p53 proteins are usually expressed at high levels in tumors, where they exert oncogen...
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Article
Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation
Several epidemiological studies have shown that high levels of melatonin, an indolic hormone secreted mainly by the pineal gland, reduce the risks of develo** cancer, thus suggesting that melatonin triggers ...
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Article
The Hippo tumor suppressor pathway: a report on ‘the second workshop on the Hippo tumor suppressor pathway’
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Article
Autonomic cardiovascular function and baroreflex sensitivity in patients with cervical dystonia receiving treatment with botulinum toxin type A
To investigate possible changes in autonomic cardiovascular regulation and cardiopulmonary baroreflex sensitivity in patients with primary cervical dystonia receiving chronic treatment with botulinum toxin typ...
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Article
Mutant p53: an oncogenic transcription factor
Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human cancers. It has become increasi...
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Article
S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation
The p53 paralogues p73, p63 and their respective truncated isoforms have been shown to be critical regulators of developmental and differentiation processes. Indeed, both p73- and p63-deficient mice exhibit se...
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Article
Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression
Mutations in the TP53 tumor suppressor gene are the most frequent genetic alteration in human cancers. These alterations are mostly missense point mutations that cluster in the DNA binding domain. There is growin...
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Article
Mutant p53 exerts its gain of function through activation of the NF-κB pathway
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Article
Nonlinear Coupling Among Heart Rate, Blood Pressure, and Respiration in Patients Susceptible to Neuromediated Syncope
The aim of this study is to evaluate the degree of coupling between the cardiovascular variability series and the respiration in subjects susceptible to neurally mediated syncope. Twenty-one informed patients ...
