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Article
Open AccessRetinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress
Retinoic acid (RA) in association with chemotherapy or with arsenic trioxide (ATO) results in high cure rates of acute promyelocytic leukemia (APL). We show that RA-induced differentiation of human leukemic ce...
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Article
Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitors
MicroRNAs (miRNAs) regulate cell proliferation, differentiation and death during development and postnatal life. The expression level of mature miRNAs results from complex molecular mechanisms, including the t...
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Article
Open AccessArgonaute 2 sustains the gene expression program driving human monocytic differentiation of acute myeloid leukemia cells
MicroRNAs are key regulators of many biological processes, including cell differentiation. These small RNAs exert their function assembled in the RNA-induced silencing complexes (RISCs), where members of Argon...
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Article
Open AccessThe microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells
Blocks in genetic programs required for terminal myeloid differentiation and aberrant proliferation characterize acute myeloid leukemia (AML) cells. 1,25-Dihydroxy-vitamin D3 (VitD3) arrests proliferation of A...
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Article
MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function
p53 mutations have profound effects on non-small-cell lung cancer (NSCLC) resistance to chemotherapeutic treatments. Mutant p53 proteins are usually expressed at high levels in tumors, where they exert oncogen...
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Chapter
Emerging Role for MicroRNAs in Acute Promyelocytic Leukemia
Hematopoiesis is highly controlled by lineage-specific transcription factors that, by interacting with specific DNA sequences, directly activate or repress specific gene expression. These transcription factors...
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Article
Use of dual-color interphase FISH for the detection of inv(16) in acute myeloid leukemia at diagnosis, relapse and during follow-up: a study of 23 patients
The value of dual-color fluorescence in situ hybridization (FISH) for the detection of inv(16), using two contigs of cosmid probes map** on both sides of the chromosome 16p breakpoint region, was evaluated in 2...
