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Article
Quantification of the uncertainty in the modelling of unstable slopes displaying marked soil heterogeneity
This study presents the application of the Boolean Stochastic Generation (BoSG) approach to the case study of the Mortisa landslide, an active earth slide flow in the Dolomites (Italy). The approach relies on ...
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Article
A new data assimilation procedure to develop a debris flow run-out model
Parameter calibration is one of the most problematic phases of numerical modeling since the choice of parameters affects the model’s reliability as far as the physical problems being studied are concerned. In ...
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Article
Mutant p53 inhibits miRNA biogenesis by interfering with the microprocessor complex
Downregulation of microRNAs (miRNAs) is commonly observed in cancers and promotes tumorigenesis suggesting that miRNAs may function as tumor suppressors. However, the mechanism through which miRNAs are regulat...
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Article
Genetic epistasis between killer immunoglobulin-like receptors and human leukocyte antigens in Kawasaki disease susceptibility
Kawasaki disease (KD) is a pediatric acute multisystemic vasculitis complicated by development of coronary artery lesions. The breakthrough theory on KD etiopathogenesis points to pathogens/environmental facto...
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Article
Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist
The TP53 tumor-suppressor gene is frequently mutated in human cancer. Missense mutations can add novel functions (gain-of-function, GOF) that promote tumor malignancy. Here we report that mutant (mut) p53 promote...
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Chapter and Conference Paper
Simplification of the Stratigraphic Profile in Geotechnical Models of Landslides: An Analysis Through a Stochastic Approach
The uncertainties in the determination of the stratigraphic profile of natural soils is one of the main problems in geotechnics, in particular for landslide characterization and modelling. The study deals with...
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Article
Open AccessTargeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications
Mitogen-activated protein kinase kinase 3 (MAP2K3, MKK3) is a member of the dual specificity protein kinase group that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic or stress-i...
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Article
Open AccessDegradation of mutant p53H175 protein by Zn(II) through autophagy
TP53, one of the most important oncosuppressors, is frequently mutated in cancer. Several p53 mutant proteins escape proteolytic degradation and are highly expressed in an aberrant conformation often acquiring pr...
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Article
HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice
Despite the tremendous potential of adenovirus (Ad) as a delivery vector for cancer gene therapy, its use in clinical settings has been limited, mainly as a result of the limited infectivity in many tumors and...
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Article
Open AccessInhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells
The phosphoinositide 3-kinases (PI3Ks) are heterodimers consisting of the catalytic subunit p110 and the regulatory subunit p85. The PI3K/Akt pathway is strongly deregulated in breast cancer (BC) representing ...
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Article
Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis
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Article
Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression
Mutations in the TP53 tumor suppressor gene are the most frequent genetic alteration in human cancers. These alterations are mostly missense point mutations that cluster in the DNA binding domain. There is growin...
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Article
p53 is involved in the differentiation but not in the differentiation-associated apoptosis of myoblasts
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Article
Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells
Fas ligand (FasL) triggers apoptosis during cytotoxicity mediated by cytotoxic T lymphocytes and during immune downregulation 1 ...
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Article
Expression of exogenous wt-p53 does not affect normal hematopoiesis: implications for bone marrow purging
Some gene therapy approaches for cancer treatment attempt to transduce onco-suppressor genes into tumor cells. A central problem of this strategy is the targeting of tumor cells to avoid damage to normal ones....
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Article
Plasma membrane fluidity of keratinocytes of normal and psoriatic skin: A study using fluorescence anisotropy of trimethylammoniumdiphenylhexatriene (TMA-DPH)
The aim of this study was to investigate plasma membrane fluidity in human keratinocytes using fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene (DPH) and its cationic derivative 1-[4-(trimethylamino)-p...
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Article
Changes of Plasma Lipids and Erythrocyte Membrane Fluidity in Psoriatic Children
ABSTRACT: Psoriasis has been associated with an abnormal plasma lipid metabolism, and changes of erythrocyte membrane lipid composition and fluidity have been shown in adult patients. To investigate whether th...
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Article
Azelaic acid in model membranes: A thermodynamical and structural study
We report a thermodynamical and structural investigation on the effect of a dicarboxylic acid, the azelaic acid, on a synthetic phosophatidylcholine in excess water condition. The results indicate that the dru...
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Article
Structural modifications in the distearoyl phosphatidyl choline liposomes induced by variable cholesterol concentration
Liposomes of distearoyl phosphatidyl choline (DSPC) in excess water and containing different quantities of cholesterol were studied by using X-ray diffraction and differential scanning calorimetry techniques. ...
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Article
Structural analysis of the Γ phase in cholesterol-distearoylphosphatidylcholine multilamellar vesicles
The interaction of cholesterol with membranes is particularly interesting as the cholesterol concentration influences membrane stability and permeability by inducing changes in the structure and dynamics of th...
