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Article
Correction: Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions
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Article
Open AccessAnalysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway
Mutations in tuberous sclerosis (TSC) genes cause the genetic disorder TSC, as well as other neoplasms, including lymphangioleiomyomatosis (LAM) and angiomyolipomas (AMLs). AMLs are benign renal tumors occur both...
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Article
Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions
The HER2/neu oncogene encodes a receptor-like tyrosine kinase whose overexpression in breast cancer predicts poor prognosis and resistance to conventional therapies. However, the mechanisms underlying aggressi...
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Article
Modeling ductal carcinoma in situ: a HER2–Notch3 collaboration enables luminal filling
A large fraction of ductal carcinoma in situ (DCIS), a non-invasive precursor lesion of invasive breast cancer, overexpresses the HER2/neu oncogene. The ducts of DCIS are abnormally filled with cells that evade a...
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Article
Specific self-antigen-driven immune response in pericardial effusion as an isolated GVHD manifestation
Pericardial effusion and cardiac tamponade have been described as GVHD manifestations in the post transplant period. Direct evidence of GVHD-related TCR or B-cell receptor clones in patients with pericardial e...
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Article
Interferon-γ-induced neuronal differentiation of human umbilical cord blood-derived progenitors
Human umbilical cord blood (HUCB) provides a source of progenitors for cell therapy. We isolated and characterized an HUCB-derived population of progenitors (HUCBNP), differentiated toward neuronal phenotype b...
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Article
Cancer cells suppress p53 in adjacent fibroblasts
The p53 tumor suppressor serves as a crucial barrier against cancer development. In tumor cells and their progenitors, p53 suppresses cancer in a cell-autonomous manner. However, p53 also possesses non-cell-au...
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Article
The CXCR4 antagonist AMD3100 impairs survival of human AML cells and induces their differentiation
The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, participate in the retention of acute myeloblastic leukemia (AML) cells within the bone marrow microenvironment and their release in...
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Article
The presence of a single PML-RARA isoform lacking exon 5 in FISH-negative APL samples
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Article
High-throughput, sensitive and quantitative assay for the detection of BCR-ABL kinase domain mutations
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Article
P53 in blind subterranean mole rats – loss-of-function versus gain-of-function activities on newly cloned Spalax target genes
A tumor suppressor gene, p53, controls cellular responses to a variety of stress conditions, including DNA damage and hypoxia, leading to growth arrest and/or apoptosis. Recently, we demonstrated that in blind su...
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Article
Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells
Tumors contain a fraction of cancer stem cells that maintain the propagation of the disease. The CD34+CD38− cells, isolated from acute myeloid leukemia (AML), were shown to be enriched leukemic stem cells (LSC...
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Article
S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation
The p53 paralogues p73, p63 and their respective truncated isoforms have been shown to be critical regulators of developmental and differentiation processes. Indeed, both p73- and p63-deficient mice exhibit se...
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Article
The UVB-induced gene expression profile of human epidermis in vivo is different from that of cultured keratinocytes
In order to obtain a comprehensive picture of the molecular events regulating cutaneous photodamage of intact human epidermis, suction blister roofs obtained after a single dose of in vivo ultraviolet (UV)B expos...
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Article
Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue
The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia, is a master regulator of the cellular network induced by DNA double-strand breaks. The ATM gene is a...
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Article
Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes
Gene expression profiling of human substantia nigra pars compacta (SNpc) from Parkinson’s disease (PD) patients, was examined employing high density microarrays. We identified alterations in the expression of ...
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Article
Multilineage hematopoietic engraftment after allogeneic peripheral blood stem cell transplantation without conditioning in SCID patients
Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. B lymphocytes engraft in ...
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Article
Tetraploid myeloid cells in donors of peripheral blood stem cells treated with rhG-CSF
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is frequently used to mobilize CD34+ cells in healthy donors and patient with malignant diseases prior to peripheral blood stem cell (PBSC) har...
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Article
Open AccessOverexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines
Despite advances in the management of solid tumours, the development of metastases continues to be the most significant problem and cause of death for cancer patients. To define genetic determinants of pulmona...
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Article
B-cell lymphoma develo** in the donor 9 years after donor-origin acute myeloid leukemia post bone marrow transplantation
Donor-cell leukemia post bone marrow transplantation is a rare event. Most of the cases reported to date have developed in cells from an HLA-matched sibling, who had no evidence of malignant disease before or ...
