Page
%P
-
Article
Ring-substituted analogs of 3,3′-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and –independent prostate cancer cells
We recently reported that novel ring-substituted analogs of 3,3′-diindolylmethane (ring-DIMs) have anti-androgenic and growth inhibitory effects in androgen-dependent prostate cancer cells. The objectives of t...
-
Article
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer
HOTAIR is a long intervening non-coding RNA (lincRNA) that associates with the Polycomb Repressive Complex 2 (PRC2) and overexpression is correlated with poor survival for breast, colon and liver cancer patien...
-
Article
Erratum: The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53
Correction to: Oncogene (2012) 31, 3265–3276; doi:10.1038/onc.2011.504; published online 14 November 2011 Since the publication of the above manuscript the authors have identified an error in the author list; ...
-
Article
The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53
The orphan nuclear receptor TR3 (NR41A and Nur77) is overexpressed in most lung cancer patients and is a negative prognostic factor for patient survival. The function of TR3 was investigated in non-small-cell ...
-
Article
Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer
The human POK family members are transcription factors with a POZ domain and zinc-fingers that act primarily as transcriptional repressors. Several members of this family are involved in oncogenesis and this p...
-
Chapter
Toxicology and Risk Assessment of POPs
Polyhalogenated industrial compounds and combustion by-products including the polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) have been identified in almost every component o...
-
Chapter and Conference Paper
Der Arylhydrocarbon Rezeptor als neue Zielscheibe zur Behandlung des Pankreaskarzinoms
The arylhydrocarbon receptor (AhR) was initially identified as a member of the adaptive metabolic and toxic response pathway to polycyclic aromatic hydrocarbons and to halogenated dibenzo-p-dioxins and dibenzo...
-
Article
Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells
Purpose: 1,3,6,8-Substituted alkyl polychlorinated dibenzofurans (PCDFs), typified by 6-methyl-1,3,8-triCDF (MCDF), inhibit 17β-estradiol (E2)-induced responses in the rodent uterus and human breast cancer cells...
-
Article
Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells
Hs578T human breast cancer cells are an oestrogen receptor (ER)-negative cell line. Treatment of these cells with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) resulted in formation of a 6.9 S nuclear aryl hydroc...
-
Chapter and Conference Paper
Cellular and Molecular Biology of Aryl Hydrocarbon (Ah) Receptor — Mediated Gene Expression
2,3,7,8- Tetr achlorodibenzo-p-dioxin (TCDD) and related compounds elicit diverse toxic and biochemical responses in laboratory animals and mammalian cells in culture. TCDD induces CYP1A1 gene expression and resu...
-
Chapter and Conference Paper
PCDDs and PCDFs: Sources and Environmental Impact
Polychlorinated dibenzo-p-dioxins (PCDDs or polyCDDs) and polychlorinated dibenzofurans (PCDFs or polyCDFs) are members of the family of halogenated aromatic chemicals which includes the polychlorinated biphenyls...
-
Chapter
Polychlorinated Biphenyls — Human Health Effects
Commercial polychlorinated biphenyls (PCBs) are formulations prepared by the chlorination of biphenyl.1–4 The chlorine content of the products are directly dependent on the relative amount of Cl2 used in the reac...
-
Chapter and Conference Paper
Polychlorinated Biphenyls: Environmental Occurrence and Analysis
Polychlorinated biphenyls (PCBs) are complex mixtures which have been identified in every component of the global ecosystem. This chapter discusses the distribution of PCBs in the environment and points out re...
-
Chapter and Conference Paper
Mammalian Biologic and Toxic Effects of PCBs
This review outlines the mammalian toxicology of PCBs and several classes of related halogenated aromatic hydrocarbons that are persistent environmental contaminants. PCBs comprise 209 chlorinated derivatives ...
-
Chapter and Conference Paper
PCBs and Human Health
Humans have been exposed to polychlorinated biphenyl (PCB) mixtures via 3 major pathways. Several thousand workers engaged in the manufacture and application of PCBs have been exposed to relatively high levels...
-
Article
Effects of individual terphenyls and polychlorinated terphenyls on rat hepatic microsomal cytochrome P-450-dependent monooxygenases: structure-activity relationships
The effects of o-, m- and p-terphenyl, 2,4-dichloro-, 2,4,6-trichloro-, 2,3,5,6-tetrachloro-, 2,3,4,6-tetrachloro-, 2,4,4'",6- tetrachloro- and 2,3,4,5-tetrachloro-p-terphenyl, 2,3,4,5-tetrachloro-m- and o-terphe...
-
Chapter
Helenalin: Mechanism of Toxic Action
Several range plants, including Hymenoxys odorata (bitterweed) and Helenium microencephalum DC (smallhead sneezeweed) contain toxic principles believed to be the etiologic agents responsible for severe losses of ...
-
Book
-
Chapter
Other Industrial Pollutants and Natural Toxins
Tris(l,3-dichloro-2-propyl)phosphate(I) and tris(2,3-dibromopropyl)-phospate(II) are industrial flame retardants which have been used to impregnate fabrics. The carcinogenicity of II resulted in its ...
-
Chapter
PCDDs and Related Compounds: Metabolism and Biochemistry
Polychlorinated dibenzo-p-dioxins and related halogenated aromatic compounds are a group of chemicals which exhibit similar physical and environmental properties and elicit a number of common toxic and biologi...
