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  1. No Access

    Article

    Scale and local modeling: new perspectives on the modifiable areal unit problem and Simpson’s paradox

    The concept of ‘spatial scale’, or simply ‘scale’ is implicit in any discussion of global versus local models. The raison d’etre of local models is that a global scale (where here ‘global’ simply refers to all lo...

    A. Stewart Fotheringham, M. Sachdeva in Journal of Geographical Systems (2022)

  2. No Access

    Article

    Myogenic transcription factors regulate pro-metastatic miR-182

    Approximately 30% of patients with soft-tissue sarcoma die from pulmonary metastases. The mechanisms that drive sarcoma metastasis are not well understood. Recently, we identified miR-182 as a driver of sarcom...

    R D Dodd, M Sachdeva, J K Mito, W C Eward, B E Brigman, Y Ma, L Dodd, Y Kim… in Oncogene (2016)

  3. No Access

    Article

    CRISPR/Cas9: molecular tool for gene therapy to target genome and epigenome in the treatment of lung cancer

    Although varied drugs and therapies have been developed for lung cancer treatment, in the past 5 years overall survival rates have not improved much. It has also been reported that lung cancer is diagnosed in ...

    M Sachdeva, N Sachdeva, M Pal, N Gupta, I A Khan, M Majumdar… in Cancer Gene Therapy (2015)

  4. No Access

    Article

    The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53

    The orphan nuclear receptor TR3 (NR41A and Nur77) is overexpressed in most lung cancer patients and is a negative prognostic factor for patient survival. The function of TR3 was investigated in non-small-cell ...

    S-O Lee, T Andey, U-H **, K Kim, M Sachdeva, S Safe in Oncogene (2012)

  5. No Access

    Article

    MicroRNA-101-mediated Akt activation and estrogen-independent growth

    MicroRNAs are gene regulators that work through a posttranscriptional repression mechanism. Dysregulation of microRNA expression could lead to a variety of disorders, in particular, human cancer, and has also ...

    M Sachdeva, H Wu, P Ru, L Hwang, V Trieu, Y-Y Mo in Oncogene (2011)

  6. No Access

    Article

    Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner

    Ubc9 is an E2-conjugating enzyme that transfers the activated small ubiquitin-like modifier (SUMO) to protein substrates, and thus it has an important function in sumoylation-mediated cellular pathways. We hav...

    S Zhu, M Sachdeva, F Wu, Z Lu, Y -Y Mo in Oncogene (2010)