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  1. No Access

    Chapter

    Further Characterization and Applications of the 4-Chlorobiphenyl Hydroxylase Assay

    Studies of the metabolism-mediated covalent binding of halobiphenyls to cellular macromolecules revealed that the in vitro metabolism of 4-chlorobiphenyl (4-CBP) by hepatic microsomes is greatly enhanced by in vi...

    A. Parkinson, L. W. Robertson, S. Safe in Biological Reactive Intermediates—II (1982)

  2. No Access

    Chapter

    Halogenated Biphenyl Metabolism

    The metabolism of xenobiotics occurs predominantly in the liver and is generally effected in two related phases. Phase I biotransformation includes oxidation, reduction and hydrolysis which either introduces o...

    S. Safe, C. Wyndham, A. Parkinson, R. Purdy… in Hydrocarbons and Halogenated Hydrocarbons … (1980)

  3. No Access

    Article

    Identification of toxic impurities in commercial Diphenylamine

    S. Safe, O. Hutzinger, J. F. S. Crocker… in Bulletin of Environmental Contamination an… (1977)

  4. No Access

    Article

    Uptake and distribution of chloronaphthalenes and their metabolites in pigs

    L. Octavio Ruzo, S. Safe, Daniel Jones… in Bulletin of Environmental Contamination an… (1976)

  5. No Access

    Article

    Metabolism of 4-chlorobiphenyl by lichens

    Eighteen lichens from a variety of habitats were treated with 4-chlorobiphenyl (4-CB). All, as determined by means of radioactive tracers, were shown to partially convert 4-CB to 4-chloro-4′-hydroxybiphenyl. O...

    W. S. G. Maass, O. Hutzinger, S. Safe in Archives of Environmental Contamination an… (1975)

  6. No Access

    Article

    Identification of metabolic dechlorination of highly chlorinated biphenyl in rabbit

    CHLOROBIPHENYLS with one to four chlorine atoms per molecule are metabolised by certain animals, plants and microorganisms but the more highly chlorinated biphenyls are rather resistant to metabolic change1.

    O. HUTZINGER, W. D. JAMIESON, S. SAFE, L. PAULMANN, R. AMMON in Nature (1974)

  7. No Access

    Article

    Lipid and alkali extractable fatty acids fromMucor rouxii: Effect of thermal changes in growth environment and age of cells

    The lipid levels of the fungusMucor rouxii are affected markedly by both the growth temperature and the age of the cells. Both chloroform-methanol extractable (fraction I) and alkali extractable (fraction II) fat...

    S. Safe in Lipids (1974)

  8. No Access

    Article

    Detection of the ergosterol and episterol isomers lichesterol and fecosterol in nystatin-resistant mutants of Neurospora crassa

    Wild-type Neurospora crassa is completely inhibited by 5 ppm nystatin. Ultraviolet-induced mutants have been isolated that grow in the presence of 60 ppm of the antibiotic. Gas-liquid chromatographic, mass spectr...

    D. C. Morris, S. Safe, R. E. Subden in Biochemical Genetics (1974)

  9. No Access

    Article

    Identification of 4-chloro-4′-hydroxybiphenyl and 4,4′-dichloro-3-hydroxybiphenyl as metabolites of 4-chloro- and 4,4′-dichlorobiphenyl fed to rats

    Identifizierung und Strukturaufklärung zweier Metaboliten von 4-Chorbiphenyl und 4,4′-Dichlorbiphenyl mittels NMR-Spektroskopie.

    S. Safe, O. Hutzinger, D. Ecobichon in Experientia (1974)

  10. No Access

    Article

    Effect of oxygen levels on the fatty acids and lipids ofMucor rouxii

    The effect of aerobic and oxygen limiting (anaerobic) growth conditions upon the fatty acid and lipid composition ofMucor rouxii has been examined. The aerobic cells contained a range of fatty acids typical of ph...

    S. Safe, J. Duncan in Lipids (1974)

  11. No Access

    Chapter

    Ion Kinetic Energy Spectroscopy: A New Mass Spectrometric Method for the Unambiguous Identification of Isomeric Chlorophenols

    Ion kinetic energy (IKE) spectroscopy is a technique which records the ionic decompositions which occur in the first field-free region of the mass spectrometer prior to the electric sector1,2. These ions can be r...

    S. Safe, W. D. Jamieson, O. Hutzinger in Mass Spectrometry and NMR Spectroscopy in … (1974)

  12. No Access

    Article

    Lipid composition ofChaetomium cochliodes: Effect of media

    The fatty acid and lipid compositions ofChaetomium cochliodes grown on three different media are compared. Although the growth media effects dramatic changes in the antibiotic production, only minor alterations i...

    S. Safe, D. Brewer in Lipids (1973)

  13. No Access

    Article

    7-Methyl-7-hexadecenoic acid: Isolation from lipids of the ocean sunfishMola mola (Linnaeus) 1758

    A fatty acid amounting to several per cent of the acids in various samples of the liver oil of the ocean sunfishMola mola was isolated and characterized as 7-methyl-7-hexadecenoic acid. This acid and the previous...

    R. G. Ackman, L. Safe, S. N. Hooper, M. Paradis, S. Safe in Lipids (1973)

  14. No Access

    Article

    A general method for the preparation of tritiated polychlorobiphenyls of high specific activity: 2,2′,5,5′-tetrachlorobiphenyl-[3H] and 2,2′,4,4′,5,5′-hexachlorobiphenyl-[3H]

    O. Hutzinger, S. Safe in Bulletin of Environmental Contamination and Toxicology (1972)

  15. No Access

    Article

    Polychlorinated Biphenyls: Photolysis of 2,4,6,2′,4′,6′-Hexachlorobiphenyl

    MANY aromatic organochlorine compounds are readily utilized or otherwise decomposed by a number of specific microorganisms. In the environment, however, these compounds are relatively stable and resistant to g...

    S. SAFE, O. HUTZINGER in Nature (1971)

  16. No Access

    Article

    Polychlorinated biphenyls: Synthesis of some individual chlorobiphenyls

    O. Hutzinger, S. Safe, V. Zitko in Bulletin of Environmental Contamination and Toxicology (1971)

  17. No Access

    Article

    Retention times and electron-capture detector responses of some individual chlorobiphenyls

    V. Zitko, O. Hutzinger, S. Safe in Bulletin of Environmental Contamination and Toxicology (1971)

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