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Article
Open AccessIntegrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids
The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the g...
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Article
Actualités en pathologie moléculaire dans les cancers du poumon non à petites cellules
Lung cancer is the leading cause of death by cancer worldwide. The vast majority of lung tumors are non-small cell lung carcinomas (NSCLC), and surgical resection remains the only effective treatment. Accordin...
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Chapter
Aspects morphologiques et moléculaires des lésions pré-invasives broncho-pulmonaires : impact sur leur évolutivité
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Article
Open AccessDifferential expression of telomerase reverse transcriptase (hTERT) in lung tumours
Human telomerase reverse transcriptase is a ribonucleoprotein that synthesises telomeric sequences, which decrease at each cell division. In cancer cells, its activity is linked to telomere maintenance leading...
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Article
Inhibitory effects of large Ca2+-activated K+-channel blockers on β-adrenergic- and NO-donor-mediated relaxations of human and guinea-pig airway smooth muscles
In human bronchi, relaxations to salbutamol and sodium nitroprusside were performed in the presence or absence of blockers of the large Ca2+-activated K+-channels (BKCa): charybdotoxin (Chtx), iberiotoxin (Ibtx)...
