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Article
Localized viral vector delivery to enhance in situ regenerative gene therapy
A lyophilization method was developed to locally release adenoviral vectors directly from biomaterials for in situ regenerative gene therapy. Adenovirus expressing a β-galactosidase reporter gene (AdLacZ) was mix...
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Chapter
Image-based Hierarchical Analysis and Design of Tissue Engineering Scaffolds
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Article
Tissue Engineered Bone Using Polycaprolactone Scaffolds Made by Selective Laser Sintering
Polycaprolactone is a bioresorbable polymer that has potential for tissue engineering of bone and cartilage. In this work, we report on the computational design and freeform fabrication of porous polycaprolact...
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Chapter and Conference Paper
Image Based Design and Manufacture of Scaffolds for Bone Reconstruction
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Article
Normal and reconstructed mandibular condyle mechanics
One approach to reconstructing a damaged mandibular condyle is to replace it with a rib graft. This procedure requires removal of the lateral pterygoid muscle. The rib graft has significantly different shape a...
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Article
Hydroxyapatite implants with designed internal architecture
Porous hydroxyapatite (HA) has been used as a bone graft material in the clinics for decades. Traditionally, the pores in these HAs are either obtained from the coralline exoskeletal patterns or from the embed...
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Chapter
Engineering Microstructures to Evaluate and Replace Trabecular Bone
Trabecular bone architecture is a significant determinant of both its effective stiffness and strength. Develo** a mathematical equation to characterize stiffness and strength dependence on architecture, kno...
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Article
Effective anisotropic elastic constants of bimaterial interphases: comparison between experimental and analytical techniques
The effective elastic constants of a bimaterial composite were experimentally measured with the goal of validating the numerical predications of these constants made by homogenization theory. Secondly, solutio...
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Article
A comparison of homogenization and standard mechanics analyses for periodic porous composites
Composite material elastic behavior has been studied using many approaches, all of which are based on the concept of a Representative Volume Element (RVE). Most methods accurately estimate effective elastic pr...