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  1. No Access

    Article

    Three years of alendronate treatment does not continue to decrease microstructural stresses and strains associated with trabecular microdamage initiation beyond those at 1 year

    The effects of a 3-year alendronate treatment on trabecular stresses/strains associated with microdamage initiation were investigated using finite element modeling (FEM). Severely damaged trabeculae in the low...

    J. O. Green, T. Diab, M. R. Allen, B. Vidakovic, D. B. Burr… in Osteoporosis International (2012)

  2. No Access

    Article

    Biomimetic tubular nanofiber mesh and platelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration

    There is a growing need for successful bone tissue engineering strategies and advanced biomaterials that mimic the structure and function of native tissues carry great promise. Successful bone repair approache...

    A. Berner, J. D. Boerckel, S. Saifzadeh, R. Steck, J. Ren… in Cell and Tissue Research (2012)

  3. No Access

    Article

    Effects of Treatment with Parathyroid Hormone 1–84 on Quantity and Biomechanical Properties of Thoracic Vertebral Trabecular Bone in Ovariectomized Rhesus Monkeys

    Osteoporosis is characterized by impaired bone quality leading to increased susceptibility to fracture, particularly of the thoracic spine. However, the lumbar spine is studied most commonly. We investigated t...

    J. Fox, M. K. Newman, C. H. Turner, R. E. Guldberg… in Calcified Tissue International (2008)

  4. No Access

    Article

    Inducible regulation of Runx2-stimulated osteogenesis

    Ex vivo gene therapy is a promising approach to orthopedic regenerative medicine. These strategies typically focus on the constitutive overexpression of osteogenic factors to induce osteoblastic differentiation a...

    C A Gersbach, J M Le Doux, R E Guldberg, A J García in Gene Therapy (2006)

  5. No Access

    Chapter and Conference Paper

    Image Based Design and Manufacture of Scaffolds for Bone Reconstruction

    S. J. Hollister, T. M. Chu, R. E. Guldberg… in IUTAM Symposium on Synthesis in Bio Solid … (2002)

  6. No Access

    Chapter

    Engineering Microstructures to Evaluate and Replace Trabecular Bone

    Trabecular bone architecture is a significant determinant of both its effective stiffness and strength. Develo** a mathematical equation to characterize stiffness and strength dependence on architecture, kno...

    S. J. Hollister, P. K. Zysset… in Noninvasive Assessment of Trabecular Bone … (2001)