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Article
Co-aggregation of major psychiatric disorders in individuals with first-degree relatives with schizophrenia: a nationwide population-based study
A previous genetic study has suggested that schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) share common disease-a...
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Article
Open AccessErratum: The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response
Correction to: Translational Psychiatry (2015) 5, e553; doi:10.1038/tp.2015.47; published online 21 April 2015 Following publication, the authors identified an error in the meta-analysis of ISPC, AMPS and STAR...
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Article
Open AccessThe International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response
Response to treatment with selective serotonin reuptake inhibitors (SSRIs) varies considerably between patients. The International SSRI Pharmacogenomics Consortium (ISPC) was formed with the primary goal of id...
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Article
Association study of polymorphisms in post-synaptic density protein 95 (PSD-95) with schizophrenia
The postsynaptic density protein 95 (PSD-95) – the prototype of this family – is a modular protein that enables anchoring of NMDA receptors, modulates NMDA receptor sensitivity to glutamate and coordinates NMD...
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Article
Association study of polymorphisms in glycine transporter with schizophrenia
Glycine acts as an obligatory co-agonist with glutamate on N-methyl-D-aspartate (NMDA) receptors. Brain glycine availability is determined by glycine transporters (GlyT1 or SLC6A9), which mediate glycine reuptake...
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Article
Lack of association of catechol-O-methyltransferase gene Val108/158Met polymorphism with schizophrenia: a family-based association study in a Chinese population
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Article
Association studies of the adenosine A2a receptor (1976T > C) genetic polymorphism in Parkinson’s disease and schizophrenia
Given the implications with respect to the pathogenesis of dopaminergic dysfunction in schizophrenia and Parkinson’s disease (PD), as well as the reciprocal antagonistic interactions between adenosine A2a rece...
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Article
Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males
The dopamine transporter (DAT) and the serotonin transporter (5-HTT) play important roles in methamphetamine (METH) dependence because they are the target of METH action. For this study, the association betwe...
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Article
Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders
The serotonin transporter (5-HTT) is the site of primary action for the selective serotonin reuptake inhibitors (SSRIs). Previous Western reports have demonstrated that the lallele of the 5-HTT gene-linked polymo...
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Article
Association study of Angiotensin I-converting enzyme polymorphism and symptomatology and antidepressant response in major depressive disorders
Angiotensin-converting enzyme (ACE) inhibitor has mood-elevating effects, and central ACE activity is increased for suicidal patients. In addition, substance P (SP), which is degraded by ACE, has been implica...
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Article
Association analysis for genetic variants of the NMDA receptor 2b subunit (GRIN2B) and Parkinson's disease
Recent studies have implicated N-methyl-D-aspartate (NMDA) receptor dysfunction in the pathogenesis and treatment of Parkinson's disease (PD). The NMDA receptor is composed of several subunits, of which, the ...
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Article
A study of alpha-adrenoceptor gene polymorphisms and Alzheimer disease
There exists considerable evidence implicating abnormalities of the alpha (α)-adrenergic system in the development of Alzheimer disease (AD). We propose to investigate potential correlations between the prese...