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  1. No Access

    Article

    Physiological functions of D-amino acid oxidases: from yeast to humans

    D-Amino acid oxidase (DAAO) is a FAD-containing flavoenzyme that catalyzes the oxidative deamination of D-isomers of neutral and polar amino acids. This enzymatic activity has been identified in most eukaryoti...

    L. Pollegioni, L. Piubelli, S. Sacchi, M. S. Pilone… in Cellular and Molecular Life Sciences (2007)

  2. No Access

    Article

    Distinct genomic events in the myeloid and lymphoid lineages in simultaneous presentation of chronic myeloid leukemia and B-chronic lymphocytic leukemia

    B Crescenzi, S Sacchi, R Marasca, P Temperani, R La Starza, C Matteucci… in Leukemia (2002)

  3. No Access

    Article

    Time-Dependent Kinetics of Tretinoin in Chronic Myelogenous Leukaemia during Intermittent Dose Scheduling

    Objective: This study investigated the pharmacokinetics of tretinoin during alternating cycles of 1 week of tretinoin treatment and 1 week drug-free in patients with Ph1+ chronic myelogenous leuk...

    Dr Mario B. Regazzi, D. Russo, I. Iacona, S. Sacchi… in Clinical Drug Investigation (1998)

  4. No Access

    Article

    All-trans retinoic acid (ATRA) in patients with chronic myeloid leukemia in the chronic phase

    Since in vitro observations indicated that all-trans retinoic acid (ATRA), especially in combination with IFNα, can exert significant suppressive effects on Ph+ cells, we investigated the effects and the pharmaco...

    D Russo, M Regazzi, S Sacchi, G Visani, M Lazzarino, G Avvisati, PG Pelicci… in Leukemia (1998)

  5. No Access

    Article

    Alfa-interferon in the treatment of essential thrombocythemia: clinical results and evaluation of its biological effects on the hematopoietic neoplastic clone

    The efficacy of alfa-interferon (alfa-IFN) in essential thrombocythemia (ET) patients has been reported by several authors. The aim of this study is to assess the magnitude of the effect of alfa-IFN on the neo...

    S Sacchi, L Gugliotta, F Papineschi, AM Liberati, S Rupoli, C Delfini… in Leukemia (1998)

  6. No Access

    Article

    Long-term follow-up results of alpha-interferon-based regimens in patients with late chronic phase chronic myelogenous leukemia

    The aim of this analysis was to evaluate the efficacy of alpha-interferon (α-IFN) regimens in late chronic phase (diagnosis >12 months) chronic myelogenous leukemia (CP-CML). Long-term follow-up results were e...

    S Sacchi, HM Kantarjian, S O’Brien, M Beran, C Koller, S Pierce, S Kornblau… in Leukemia (1997)

  7. No Access

    Article

    A prospective comparison between treatment with phlebotomy alone and with interferon-alpha in patients with polycythemia vera

    Interferon alpha (α-IFN) is increasingly used for the treatment of patients affected by polycythemia vera (PV). As prior studies are difficult to interpret in view of the lack of appropriate controls, we under...

    S. Sacchi, P. Leoni, M. Liberati, A. Riccardi, A. Tabilio… in Annals of Hematology (1994)

  8. No Access

    Article

    Sustained complete hematological remission in essential thrombocythemia after discontinuation of long-term α-IFN treatment

    In essential thrombocythemia patients α-IFN rapidly reduces platelet count, and it is also able to maintain a low count during long-term treatment. In order to verify if long-term IFN treatment can produce sus...

    S. Sacchi, A. Tabilio, P. Leoni, A. Riccardi, A. Vecchi, C. Messora… in Annals of Hematology (1993)

  9. No Access

    Article

    Interferon alpha-2b in the long-term treatment of essential thrombocythemia

    We treated 35 patients affected with essential thrombocythemia (ET) with interferon (IFN) alpha-2b. Our treatment scheme consisted of (a) a 6-month induction phase and (b) a continuous maintenance phase. Durin...

    S. Sacchi, A. Tabilio, P. Leoni, A. Riccardi, A. Vecchi, C. Messora… in Annals of Hematology (1991)

  10. No Access

    Article

    Sinus histiocytosis with massive lymphadenopathy: Immunological, cytogenetic and molecular studies

    We describe a case of “sinus histiocytosis with massive lymphadenopathy” (SHML) studied by immunohistochemical, cytogenetic and molecular analysis. The immunophenoty** showed that the lymph node histiocytes ...

    S. Sacchi, T. Artusi, L. Selleri, P. Temperani, P. Zucchini, A. Vecchi, G. Emilia… in Blut (1990)

  11. No Access

    Article

    In vivo andin vitro HeNe laser effects on phagocyte functions

    The goal of this work was to evaluate the effect of helium-neon (HeNe) laser irradiation on immunocompetent cells. We used the in vivo skin window method and in vitro granulocyte function tests. The study of c...

    G. Ricevuti, A. Mazzone, C. Monaia, P. Fratino, R. Degiulio, R. Dell'acqua… in Inflammation (1989)