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  1. No Access

    Article

    Overexpression of PAI-1 prevents the development of abdominal aortic aneurysm in mice

    Vessel wall inflammation and matrix destruction are critical to abdominal aortic aneurysm (AAA) formation and rupture. We have previously shown that urokinase plasminogen activator (uPA) is highly expressed in...

    H S Qian, J-M Gu, P Liu, K Kauser, M Halks-Miller, R Vergona, M E Sullivan… in Gene Therapy (2008)

  2. No Access

    Article

    Effect of viral dose on neutralizing antibody response and transgene expression after AAV1 vector re-administration in mice

    Neutralizing antibodies (nAB) at the time of administration hamper the effectiveness of adeno-associated virus (AAV) as a clinical DNA delivery system. The present study was designed to investigate if AAV re-a...

    H Petry, A Brooks, A Orme, P Wang, P Liu, J **e, P Kretschmer, H S Qian… in Gene Therapy (2008)

  3. No Access

    Chapter and Conference Paper

    A Facile Synthesis of Multicolor Polystyrene Microspheres Encapsulating Upconversion Fluorescent Nanoparticles

    Monodisperse polystyrene (PS) microspheres encapsulating rare-earth ion doped β-NaYF4 upconversion fluorescent nanocrystals, with ca. 400 nm in diameter, have been synthesized successfully using a microemulsion p...

    H. S. Qian, Z. Q. Li, Yong Zhang in 4th Kuala Lumpur International Conference … (2008)

  4. No Access

    Article

    Regulated expression of the interferon-β gene in mice

    A single plasmid regulated expression vector based upon a mifepristone-inducible two plasmid system, termed pBRES, has been constructed and tested in mice using murine interferon-b (mIFNb) as the transgene. Th...

    R N Harkins, P Szymanski, H Petry, A Brooks, H S Qian, C Schaefer… in Gene Therapy (2008)

  5. No Access

    Chapter

    Role of Endothelial Nitric Oxide in Bone Marrow-Derived Progenitor Cell Mobilization

    Mobilization and recruitment of bone marrow-derived progenitor cells (BMDPCs) play an important role in postischemic tissue repair. Patients with coronary artery disease (CAD) or peripheral vascular disease (P...

    M. Monterio de Resende, L. -Y. Huw, H. -S. Qian… in Bone Marrow-Derived Progenitors (2007)

  6. No Access

    Chapter and Conference Paper

    Promotion of Frontier Science Research by Aid of Automatic Program Generation Technology

    Based on a new DIY concept for software development [1], an automatic program-generating technology attached on a software system called as Finite Element Program generator (FEPG) provides a platform of developin...

    B. X. Wu, H. S. Qian, S. Wan in Computational Methods in Engineering & Science (2007)

  7. No Access

    Article

    Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase gene

    Gene delivery of angiogenic growth factors is a promising approach for the treatment of ischemic cardiovascular diseases. However, success of this new therapeutic principle is hindered by the lack of critical ...

    H S Qian, P Liu, L-Y Huw, A Orme, M Halks-Miller, S M Hill, F **… in Gene Therapy (2006)