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Article
Open AccessA novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage
The development of nonapoptotic programmed cell death inducers as anticancer agents has emerged as a cancer therapy field. Ferroptosis, ferrous ion-driven programmed cell death that is induced by redox imbalan...
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Article
Shotgun proteomic analysis using human serum from type 2 diabetes mellitus patients
Type 2 diabetes mellitus (T2DM), also known as adult-onset diabetes or noninsulin-dependent diabetes mellitus, is characterized by hyperglycemia and insulin resistance. Protein biomarker screening plays an ess...
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Article
Open AccessMRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner
MRE11, the nuclease component of RAD50/MRE11/NBS1 DNA repair complex which is essential for repair of DNA double-strand-breaks in normal cells, has recently garnered attention as a critical factor in solid tum...
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Article
Activation and Inhibition of ATM by Phytochemicals: Awakening and Slee** the Guardian Angel Naturally
Double-stranded breaks (DSBs) are cytotoxic DNA lesions caused by oxygen radicals, ionizing radiation, and radiomimetic chemicals. Increasing understanding of DNA damage signaling has provided an ever-expandin...
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Article
Open AccessIdentification of an iridium(III) complex with anti-bacterial and anti-cancer activity
Group 9 transition metal complexes have been widely explored as therapeutic agents due to their unique geometry, their propensity to undergo ligand exchanges with biomolecules and their diverse steric and elec...
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Article
Inhibitor IκBα Promoter Functional Polymorphisms in Patients with Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammation disease that may involve extra-articular organs in addition to joints. Many proinflammatory cytokines are involved in the inflammatory process of RA. IκBα co...
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Article
IkBα promoter polymorphisms in patients with ankylosing spondylitis
The purpose of this study is to investigate the association of IκBα with the development of ankylosing spondylitis (AS) in Taiwan. One hundred and fifty-four patients with AS and 112 unrelated healthy controls we...
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Article
IkBα Promoter Polymorphisms in Patients with Primary Sjögren’s Syndrome
To investigate the association of IkBα promoter polymorphisms with the development of primary Sjögren’s syndrome in Taiwan, 98 patients with primary Sjögren’s syndrome and 110 unrelated healthy controls were enro...
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Article
IκBα Promoter Polymorphisms in Patients with Systemic Lupus Erythematosus
To investigate the associations of IκBα gene polymorphisms with the development and clinical manifestations of systemic lupus erythematosus (SLE), 110 patients with SLE and 120 unrelated healthy controls were enr...
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Article
Polymorphisms of Genes for Programmed Cell Death 1 Ligands in Patients with Rheumatoid Arthritis
To investigate the role of ligands for programmed cell death 1 (PD-L) in the pathogenesis of rheumatoid arthritis (RA), 129 patients with RA and 125 unrelated healthy controls were enrolled in this study. The PD-...
