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Article
Skin-resident innate lymphoid cells converge on a pathogenic effector state
Tissue-resident innate lymphoid cells (ILCs) help sustain barrier function and respond to local signals. ILCs are traditionally classified as ILC1, ILC2 or ILC3 on the basis of their expression of specific tra...
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Article
Open AccessThe induction and function of the anti-inflammatory fate of TH17 cells
TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or....
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Article
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, but they have only modest efficacy and limited tolerability1,2. In an effort to identify alternative ...
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Article
Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Author Correction: Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
Direct recognition of invading pathogens by innate immune cells is a critical driver of the inflammatory response. However, cells of the innate immune system can also sense their local microenvironment and res...
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Article
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
Activated CD4 T cells proliferate rapidly and remodel epigenetically before exiting the cell cycle and engaging acquired effector functions. Metabolic reprogramming from the naive state is required throughout ...
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Article
The translation of non-canonical open reading frames controls mucosal immunity
The annotation of the mammalian protein-coding genome is incomplete. Arbitrary size restriction of open reading frames (ORFs) and the absolute requirement for a methionine codon as the sole initiator of transl...
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Article
Open AccessThe E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
The NLRP3 inflammasome has an important function in inflammation by promoting the processing of pro-IL-1β and pro-IL-18 to their mature bioactive forms, and by inducing cell death via pyroptosis. Here we show ...
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Article
The lock-washer: a reconciliation of the RIG-I activation models
RIG-I belongs to a type of intracellular pattern recognition receptors involved in the recognition of viral RNA by the innate immune system. A report by Peisley et al. published in Nature provides the crystal str...
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Article
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis
The E3 ubiquitin ligases that modify the kinase RIP2 downstream of the receptor Nod2 remain unclear. Moynagh and colleagues show that Pellino3 ubiquitinates RIP2 for Nod2-induced activation of the transcriptio...
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Article
Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons
Signaling through toll-like receptors induces cytokines and type I interferon. Moynagh and colleagues show that the E3 ubiquitin ligase Pellino3 specifically represses the expression of type I interferon in re...
