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Chapter and Conference Paper
Inferring Metabolic States from Single Cell Transcriptomic Data via Geometric Deep Learning
The ability to measure gene expression at single-cell resolution has elevated our understanding of how biological features emerge from complex and interdependent networks at molecular, cellular, and tissue sca...
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Article
Inflammasome activation in infected macrophages drives COVID-19 pathology
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine production, viral RNA and a sustained interferon (IFN) response, all of which are recapitulated and required for patholog...
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Article
Skin-resident innate lymphoid cells converge on a pathogenic effector state
Tissue-resident innate lymphoid cells (ILCs) help sustain barrier function and respond to local signals. ILCs are traditionally classified as ILC1, ILC2 or ILC3 on the basis of their expression of specific tra...
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Article
Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Author Correction: Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
Direct recognition of invading pathogens by innate immune cells is a critical driver of the inflammatory response. However, cells of the innate immune system can also sense their local microenvironment and res...
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Article
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
Activated CD4 T cells proliferate rapidly and remodel epigenetically before exiting the cell cycle and engaging acquired effector functions. Metabolic reprogramming from the naive state is required throughout ...
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Article
The translation of non-canonical open reading frames controls mucosal immunity
The annotation of the mammalian protein-coding genome is incomplete. Arbitrary size restriction of open reading frames (ORFs) and the absolute requirement for a methionine codon as the sole initiator of transl...
