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  1. No Access

    Article

    Developmental dynamics of RNA translation in the human brain

    The precise regulation of gene expression is fundamental to neurodevelopment, plasticity and cognitive function. Although several studies have profiled transcription in the develo** human brain, there is a g...

    Erin E. Duffy, Benjamin Finander, GiHun Choi, Ava C. Carter… in Nature Neuroscience (2022)

  2. No Access

    Article

    Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor

    Many unannotated microproteins and alternative proteins (alt-proteins) are coencoded with canonical proteins, but few of their functions are known. Motivated by the hypothesis that alt-proteins undergoing regu...

    **ongwen Cao, Alexandra Khitun, Cecelia M. Harold… in Nature Chemical Biology (2022)

  3. Article

    Open Access

    Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

    Thousands of human small and alternative open reading frames (smORFs and alt-ORFs, respectively) have recently been annotated. Many alt-ORFs are co-encoded with canonical proteins in multicistronic configurati...

    **ongwen Cao, Alexandra Khitun, Yang Luo, Zhenkun Na… in Nature Communications (2021)

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  4. No Access

    Article

    The translation of non-canonical open reading frames controls mucosal immunity

    The annotation of the mammalian protein-coding genome is incomplete. Arbitrary size restriction of open reading frames (ORFs) and the absolute requirement for a methionine codon as the sole initiator of transl...

    Ruaidhrí Jackson, Lina Kroehling, Alexandra Khitun, Will Bailis, Abigail Jarret… in Nature (2018)