12 Result(s)
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Rosalia C. M. Simmen
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Living Reference Work Entry In depth
Endometriosis and Endometriosis-Associated Tumors
Endometriosis is a chronic, estrogen-dependent, inflammatory disorder that affects ~10% of reproductive-aged women. The condition, characterized by the presence of endometrial glands and stroma outside of the ...
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Article
Open AccessA Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression
Endometriosis (ENDO) is a chronic estrogen-dependent gynecological condition that affects reproductive-age women, causing pelvic pain, infertility, and increased risk for ovarian cancer. Diabetes mellitus (DM)...
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Chapter
Endometriosis and Endometriosis-Associated Tumors
Endometriosis is a chronic gynecologic disorder that affects ~10% of adolescent girls and premenopausal women. The condition, classically defined as the presence of endometrial glands and stroma outside of the...
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Article
Open AccessMalic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice
Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented int...
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Chapter
Maternal Metabolic State and Cancer Risk: An Evolving Manifestation of Generational Impact
Metabolic stress in the early-life environment as a consequence of maternal overnutrition and obesity leads to an increased risk of adult metabolic syndrome in offspring. Given the greater risk for cancer deve...
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Article
Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells
Colorectal cancer (CRC) is a disease whose genesis may include metabolic dysregulation. Cancer stem cells are attractive targets for therapeutic interventions since their aberrant expansion may underlie tumor ...
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Article
The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein
Breast cancer is the leading cause of cancer deaths in women. Diet and lifestyle are major contributing factors to increased breast cancer risk. While mechanisms underlying dietary protection of mammary tumor ...
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Chapter
Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer
The increasing cognizance that diet (and lifestyle) can modify breast cancer risk and progression has motivated many breast cancer patients to take increasing personal control of the direction of their therapi...
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Chapter
Nutrition and the IGF System in Reproduction
Nutrition interacts with the IGF system to modify reproductive processes.
The relative roles of t...
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Article
A distal regulatory region of the insulin-like growth factor binding protein-2 (IGFBP-2) gene interacts with the basic helix-loop-helix transcription factor, AP-4
Insulin-like growth factor binding protein-2 (IGFBP-2), the predominant IGFBP in the fetal circulation and an induced protein during several types of malignancies, belongs to a family of structurally related p...
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Chapter and Conference Paper
IGF System in Periimplantation Uterus and Embryonic Development
The periimplantation period represents a critical point in pregnancy when biological interactions between the embryo and the maternal uterus must be coordinated to ensure a suitable environment for implantatio...
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Chapter
IGFs in Pregnancy: Developmental Expression in Uterus and Mammary Gland and Paracrine Actions during Embryonic and Neonatal Growth
The insulin-like growth factors (IGF-I, IGF-II) are structural homologs of insulin that are mitogenic in vivo and in vitro 1. These peptides are also characterized by other actions which include the...
