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Article
Open AccessMetformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells
Metformin (MET) is increasingly implicated in reducing the incidence of multiple cancer types in patients with diabetes. However, similar effects of MET in non-diabetic women with endometrial cancer (EC) remai...
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Article
Open AccessMalic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice
Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented int...
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Article
Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells
Colorectal cancer (CRC) is a disease whose genesis may include metabolic dysregulation. Cancer stem cells are attractive targets for therapeutic interventions since their aberrant expansion may underlie tumor ...
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Chapter
Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer
The increasing cognizance that diet (and lifestyle) can modify breast cancer risk and progression has motivated many breast cancer patients to take increasing personal control of the direction of their therapi...
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Article
Dietary soy protein induces hepatic lipogenic enzyme gene expression while suppressing hepatosteatosis in obese female Zucker rats bearing DMBA-initiated mammary tumors
Fatty liver is associated with obesity and breast cancer. We used an obese rat model of mammary cancer to examine whether hepatosteatosis is modifiable by diet and associated with altered expression of hepatic...
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Article
Open AccessLack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon
Blueberries may lower relative risk for cancers of the gastrointestinal tract. Previous work indicated an inhibitory effect of consumed blueberry (BB) on formation of aberrant crypt foci (ACF) in colons of mal...
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Article
Open AccessThe Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression
Krüppel-like factor 9 (KLF9) is a transcriptional regulator of uterine endometrial cell proliferation, adhesion and differentiation; processes essential for pregnancy success and which are subverted during tum...
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Article
Open AccessDietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis
We previously reported that lifetime consumption of soy proteins or whey proteins reduced the incidence of azoxymethane (AOM)-induced colon tumors in rats. To obtain insights into these effects, global gene ex...
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Article
Open AccessThe planetary biology of cytochrome P450 aromatases
Joining a model for the molecular evolution of a protein family to the paleontological and geological records (geobiology), and then to the chemical structures of substrates, products, and protein folds, is em...
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Chapter
Nutrition and the IGF System in Reproduction
Nutrition interacts with the IGF system to modify reproductive processes.
The relative roles of t...
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Chapter and Conference Paper
IGF System in Periimplantation Uterus and Embryonic Development
The periimplantation period represents a critical point in pregnancy when biological interactions between the embryo and the maternal uterus must be coordinated to ensure a suitable environment for implantatio...
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Article
Characterization of ixodid tick salivary-gland gene products, using recombinant DNA technology
Ticks secrete an array of lesion-maintenance factors into the host via the salivary glands while feeding, some of which elicit an immune response by the host that adversely affects the ability of the tick to f...
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Chapter
IGFs in Pregnancy: Developmental Expression in Uterus and Mammary Gland and Paracrine Actions during Embryonic and Neonatal Growth
The insulin-like growth factors (IGF-I, IGF-II) are structural homologs of insulin that are mitogenic in vivo and in vitro 1. These peptides are also characterized by other actions which include the...
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Chapter
Antibody-Screening cDNA Libraries
Molecular cloning and ancillary techniques offer an attractive alternative in studying many biological phenomena. Successful molecular cloning of genes encoding proteins for which amino acid sequence data are ...
