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Article
Detection of breast cancer stem cell gene mutations in circulating free DNA during the evolution of metastases
Limited knowledge exists on the detection of breast cancer stem cell (BCSC)-related mutations in circulating free DNA (cfDNA) from patients with advanced cancers. Identification of new cancer biomarkers may al...
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Article
Open AccessEvaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models
Breast cancer has been considered not highly immunogenic, and few patients benefit from current immunotherapies. However, new strategies are aimed at changing this paradigm. In the present study, we examined t...
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Article
Open AccessInhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) is associated with poor survival in patients with breast c...
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Article
Open AccessErratum to: Dual HER2 blockade: preclinical and clinical data
No abstract.
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Article
Open AccessThree-Dimensional In Vitro Co-Culture Model of Breast Tumor using Magnetic Levitation
In this study, we investigate a novel in vitro model to mimic heterogeneous breast tumors without the use of a scaffold while allowing for cell-cell and tumor-fibroblast interactions. Previous studies have shown ...
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Article
Open AccessDual HER2 blockade: preclinical and clinical data
The estrogen receptor and human epidermal growth factor receptor (HER) signaling pathways are the dominant drivers of cell proliferation and survival in the majority of human breast cancers. Not surprisingly, ...
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Article
The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein
Breast cancer is the leading cause of cancer deaths in women. Diet and lifestyle are major contributing factors to increased breast cancer risk. While mechanisms underlying dietary protection of mammary tumor ...
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Article
A gene transcription signature of obesity in breast cancer
Obesity is thought to contribute to worse disease outcome in breast cancer as a result of increased levels of adipocyte-secreted endocrine factors, insulin, and insulin-like growth factors (IGFs) that accelera...
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Article
Epithelial-mesenchymal transition, cancer stem cells and treatment resistance
Breast cancer relapse, in a large number of patients, after initial response to standard of care therapy warrants development of novel therapies against recurrent and metastatic cancer. Cancer stem cells (CSCs...
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Article
Treatment Resistance in Stem Cells and Breast Cancer
Cancer stem cells are resistant to current chemotherapy and radiation regimens available for breast cancer, making it imperative to study the mechanisms of resistance and development of therapeutic strategies ...
