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Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer

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Cancer Chemoprevention and Treatment by Diet Therapy

Part of the book series: Evidence-based Anticancer Complementary and Alternative Medicine ((ACAM,volume 5))

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Abstract

The increasing cognizance that diet (and lifestyle) can modify breast cancer risk and progression has motivated many breast cancer patients to take increasing personal control of the direction of their therapies after diagnosis and surgery. While this has certain advantages, including higher compliance to prescribed drugs and improvements in emotional and mental well-being, it predicates the need for increased understanding of the benefits of particular diets and dietary regimen to the treatment programs and for improved translation of data obtained from studies with animal models into clinical settings. Epidemiological studies have linked high consumption of soy-rich foods to the lower incidence of breast cancer in Asia relative to that in Western countries. The potential of soy-rich foods as breast cancer protective when dietary exposure occurs early in life, has resulted in driving the use of soy and its associated bioactive components, specifically the isoflavone genistein, as chemopreventive agents or as adjuvants to conventional drug therapies. Bioactive components in soy foods may affect hormone and non-hormone-mediated mechanisms. However, their overall biological outcomes remain not well-understood and at times, contradictory, due to distinct physiological contexts and doses of exposure, multiple targets, and inconsistent measures of relevant endpoints. Here we provide an argument in support of the potential use of soy foods for breast cancer patients based on the review of the current literature as well as raise caveats that must be addressed for its successful application as standard-of-care treatment.

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References

  • Ablett MP, Singh JK, Clarke RB (2012) Stem cells in breast tumours: are they ready for the clinic? Eur J Cancer 48:2104–2116

    PubMed  CAS  Google Scholar 

  • Adams KF, Lampe PD, Newton KM, Ylvisaker JT, Feld A, Myerson D et al (2005) Soy protein containing isoflavones does not decrease epithelial cell proliferation in a randomized control trial. Am J Clin Nutr 82:620–626

    PubMed  CAS  Google Scholar 

  • Barker DJ (2007) The origins of the developmental origins theory. J Intern Med 261:412–417

    PubMed  CAS  Google Scholar 

  • Berner C, Aurmüller E, Gnauck A, Nestelberger M, Just A, Haslberger AG (2010) Epigenetic control of estrogen receptor expression and tumor suppressor genes is modulated by bioactive food components. Ann Nutr Metab 57:183–189

    PubMed  CAS  Google Scholar 

  • Blackburn GL, Copeland T, Khaodhiar L, Buckley RB (2003) Diet and breast cancer. J Womens Health 12:183–192

    Google Scholar 

  • Bosviel R, Dumollard E, Déchelotte P, Bignon YJ, Bernard-Gallon D (2012) Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer? OMICS 16:235–244

    PubMed  CAS  Google Scholar 

  • Boué SM, Tilghman SL, Eliot S, Zimmerman MC, Williams KY, Payton-Stewart F et al (2009) Identification of glycinol in elicited soybean (Glycine Max). Endocrinology 150:2446–2453

    PubMed  Google Scholar 

  • Brennan SF, Cantwell MM, Cardwell CR, Velentzis LS, Woodside JV (2010) Dietary patterns and breast cancer risk. Am J Clin Nutr 91:1294–1302

    PubMed  CAS  Google Scholar 

  • Caan BJ, Natarajan L, Parker B, Gold EB, Thomson C, Newman V et al (2011) Soy food consumption and breast cancer prognosis. Cancer Epidemiol Biomarkers Prev 20:854–858

    PubMed  CAS  Google Scholar 

  • Colli JL, Amling CL (2009) Chemoprevention of prostate cancer: what can be recommended to patients? Curr Urol Rep 10:165–171

    PubMed  Google Scholar 

  • Conklin M, Keely P (2012) Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers. Cell Adhes Migr 6:249–260

    Google Scholar 

  • Constantinous AI, White BE, Tonetti D, Yang Y, Liang W, Li W et al (2005) The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours. Eur J Cancer 41:647–654

    Google Scholar 

  • Creighton CJ, Sada YH, Zhang Y, Tsimelzon A, Wong H, Dave B et al (2012) A gene transcription signature of obesity in breast cancer. Breast Cancer Res Treat 132:993–1000

    PubMed  CAS  Google Scholar 

  • Dagdemir A, Durif J, Ngollo M, Bignon YJ, Bernard-Gallon D (2013) Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines. Epigenomics 5:51–63

    Google Scholar 

  • Damonte P, Hodgson JG, Chen JQ, Young LJ, Cardiff RD, Borowsky AD (2008) Mammary carcinoma behavior is programmed in the precancer stem cell. Breast Cancer Res 10:R50

    PubMed  Google Scholar 

  • Dave B, Eason RR, Till SR, Geng Y, Velarde MC, Badger TM et al (2005) The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis 26:1793–1803

    PubMed  CAS  Google Scholar 

  • Day JK, Bauer AM, DesBordes C, Zhuang Y, Kim BE, Newman LG et al (2002) Genistein alters methylation patterns in mice. J Nutr 132(Suppl 8):2419S–2423S

    PubMed  CAS  Google Scholar 

  • Dia VP, Mejia EG (2010) Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression. Cancer Lett 295:44–53

    PubMed  CAS  Google Scholar 

  • Dijkstra SC, Lampe JW, Ray RM, Brown R, Wu C, Chen C et al (2010) Biomarkers of dietary exposure are associated with lower risk of breast fibroadenomas in Chinese women. J Nutr 140:1302–1310

    PubMed  CAS  Google Scholar 

  • Dong JY, Qin LQ (2011) Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat 125:315–323

    PubMed  CAS  Google Scholar 

  • Du M, Yang X, Hartman JA, Cooke PS, Doerge DR, Ju YH et al (2012) Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice. Carcinogenesis 33:895–901

    PubMed  CAS  Google Scholar 

  • Duncan AM, Merz BE, Xu X, Nagel TC, Phipps WR, Kurzer MS (1999) Soy isoflavones exert modest hormonal effects in premenpausal women. J Clin Endocrinol Metab 84:192–197

    PubMed  CAS  Google Scholar 

  • Fersching DM, Nagel D, Siegele B, Salat C, Heinemann V, Holdenrieder S et al (2012) Apoptosis-related biomarkers sFAS, MIF, ICAM-1 and PAI-1 in serum of breast cancer patients undergoing neoadjuvant chemotherapy. Anticancer Res 32:2047–2058

    PubMed  CAS  Google Scholar 

  • Galvez AF, de Lumen BO (1999) A soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells. Nat Biotechnol 17:495–500

    PubMed  CAS  Google Scholar 

  • Galvez AF, Chen N, Macasieb J, de Lumen BO (2001) Chemopreventive property of a soybean peptide (Lunasin) that binds to deacetylated histones and inhibits acetylation. Cancer Res 61:7473–7478

    PubMed  CAS  Google Scholar 

  • Gann PH, Kazer R, Chatterton R, Gapstur S, Thedford K, Helenowski I et al (2005) Sequential, randomized trial of a low-fat, high-fiber diet and soy supplementation: effects on circulating IGF-I and its binding proteins in premenopausal women. Int J Cancer 116:297–303

    PubMed  CAS  Google Scholar 

  • Guha N, Kwan ML, Quesenberry CP Jr, Weltzien EK, Castillo AL, Caan BJ (2009) Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study. Breast Cancer Res Treat 118:395–405

    PubMed  CAS  Google Scholar 

  • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674

    PubMed  CAS  Google Scholar 

  • Hennighausen L, Robinson GW (2001) Signaling pathways in mammary gland development. Dev Cell 1:467–475

    PubMed  CAS  Google Scholar 

  • Hilakivi-Clarke L, De Assis S (2006) Fetal origins of breast cancer. Trends Endocrinol Metab 17:340–348

    PubMed  CAS  Google Scholar 

  • Hilakivi-Clarke L, Andrade JE, Helferich W (2010) Is soy consumption good or bad for the breast? J Nutr 140:2326S–2334S

    PubMed  CAS  Google Scholar 

  • Hooper L, Madhavan G, Tice JA, Leinster SJ, Cassidy A (2010) Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Hum Reprod Update 16:745–760

    PubMed  CAS  Google Scholar 

  • Hortobagyi GN, de la Garza SJ, Pritchard K, Amadori D, Haidinger R, Hudis CA et al (2005) The global breast cancer burden: variations in epidemiology and survival. Clin Breast Cancer 6:391–401

    PubMed  Google Scholar 

  • Howard TD, Ho SM, Zhang L, Chen J, Cui W, Slager R et al (2011) Epigenetic changes with dietary soy in cynomolgus monkeys. PLoS One 6:e26791

    PubMed  CAS  Google Scholar 

  • Hsieh CC, Hernάndez-Ledesma B, Jeong HJ, Park JH, de Lumen BO (2010a) Complementary roles in cancer prevention: protease inhibitor makes the cancer preventive peptide lunasin bioavailable. PLoS One 5:e8890

    PubMed  Google Scholar 

  • Hsieh CC, Hernάndez-Ledesma B, de Lumen BO (2010b) Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact 18:127–134

    Google Scholar 

  • Jeong HJ, Jeong JB, Kim DS, de Lumen BO (2007) Inhibition of core histone acetylation by the cancer preventive peptide lunasin. J Agric Food Chem 55:632–637

    PubMed  CAS  Google Scholar 

  • Jeong HJ, Jeong JB, Hsieh CC, Hernάndez-Ledesma B, de Lumen BO (2010) Lunasin is present in barley and is bioavailable and bioactive in in vivo and in vitro studies. Nutr Cancer 62:1113–1119

    PubMed  CAS  Google Scholar 

  • Jeschke J, Van Neste L, Glöckner SC, Dhir M, Calmon MF, Deregowski V et al (2012) Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen. Epigenetics 7:701–709

    PubMed  CAS  Google Scholar 

  • Kang JH, Han IH, Sung MK, Yoo H, Kim YG, Kim JS et al (2008) Soyben saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP-2. Cancer Lett 261:84–92

    PubMed  CAS  Google Scholar 

  • Kang X, Zhang Q, Wang S, Huang X, ** S (2010) Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy. CMAJ 182:1857–1862

    PubMed  Google Scholar 

  • Kang HB, Zhang YE, Yang JD, Lu KL (2012) Study on soy isoflavone consumption and risk of breast cancer and survival. Asian Pac J Cancer 13:995–998

    Google Scholar 

  • Khan SA, Chatterton RT, Michel N, Bryk M, Lee O, Ivancic D et al (2012) Soy isoflavone supplementation for breast cancer risk reduction: a randomized phase II trial. Cancer Prev Res 5:309–319

    CAS  Google Scholar 

  • Korde LA, Wu AH, Fears T, Nomura AM, West DW, Kolonel LN et al (2009) Childhood soy intake and breast cancer risk in Asian American women. Cancer Epidemiol Biomarkers Prev 18:1050–1059

    PubMed  CAS  Google Scholar 

  • Lamartiniere CA (2002) Timing of exposure and mammary cancer risk. J Mammary Gland Biol Neoplasia 7:67–76

    PubMed  Google Scholar 

  • Lee SA, Shu XO, Li H, Yang G, Cai H, Wen W et al (2009) Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai women’s health study. Am J Clin Nutr 89:1920–1926

    PubMed  CAS  Google Scholar 

  • Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N et al (2002) Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development 129:4159–4170

    PubMed  CAS  Google Scholar 

  • Lin SY, **a W, Wang JC, Kwong KY, Spohn B, Wen Y et al (2000) Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci USA 97:4262–4266

    PubMed  CAS  Google Scholar 

  • Liu DC, Yang ZL (2011) Overexpression of EZH2 and loss of expression of PTEN is associated with invasion, metastasis, and poor progression of gallbladder adenocarcinoma. Pathol Res Pract 207:472–478

    PubMed  CAS  Google Scholar 

  • Martinez-Montemayor MM, Otero-Franqui E, Martinez J, DeLaMota-Peynado A, Cubano LA, Dharmawardhana S (2010) Individual and combined soy isoflavones exert differential effects on metastatic cancer progression. Clin Exp Metastasis 27:465–480

    PubMed  CAS  Google Scholar 

  • Maskarinec G, Takata Y, Murphy SP, Franke AA, Kaaks R (2005) Insulin-like growth factor-1 and binding protein-3 in a two-year soya intervention among premenopausal women. Br J Nutr 94:362–367

    PubMed  CAS  Google Scholar 

  • Maskarinec G, Berheus M, Steinberg FM, Amato P, Cramer MK, Lewis RD et al (2009) Various doses of soy isoflavones do not modify mammographic density in postmenopausal women. J Nutr 135:981–986

    Google Scholar 

  • Mochizuki Y, Maebuchi M, Kohno M, Hirotsuka M, Wadahama H, Moriyama T et al (2009) Changes in lipid metabolism by soy beta-conglycinin-derived peptides in HepG2 cells. J Agric Food Chem 57:1473–1480

    PubMed  CAS  Google Scholar 

  • Montales MTE, Rahal OM, Kang J, Rogers TJ, Prior RL, Wu X et al (2012) Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggest diet-mediated targeting of cancer stem-like/progenitor cells. Carcinogenesis 33:652–660

    PubMed  CAS  Google Scholar 

  • Morimoto Y, Conroy SM, Pagano IS, Franke AA, Stanczyk FZ, Maskarinec G (2011) Influence of diet on nipple aspirate fluid production and estrogen levels. Food Funct 2:665–670

    PubMed  CAS  Google Scholar 

  • Murill WB, Brown NM, Zhang JX, Manzolillo PA, Barnes S, Lamartiniere CA (2007) Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis 28:1046–1051

    Google Scholar 

  • Nadal R, Fernandez A, Sanchez-Rovira P, Salido M, Rodriguez M, Garcia-Puche JL et al (2012) Biomarkers characterization of circulating tumour cells in breast cancer patients. Breast Cancer Res 14:R71

    PubMed  CAS  Google Scholar 

  • Nair V (2004) Soy and cancer survivors: dietary supplementation with fermented soy nutraceutical, Haelan951 in patients who survived terminal cancers. Townsend Lett Doctors Patients 256:48–58

    Google Scholar 

  • Nechuta SJ, Caan BJ, Chen WY, Lu W, Chen Z, Kwan ML et al (2012) Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women. Am J Clin Nutr 96:123–132

    PubMed  CAS  Google Scholar 

  • Nishio K, Niwa Y, Toyoshima H, Tamakoshi K, Kondo T, Yatsuya H et al (2007) Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) study. Cancer Causes Control 18:801–808

    PubMed  Google Scholar 

  • Pabona JM, Dave B, Su Y, Montales MT, de Lumen BO, de Mejia EG et al (2013) The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein. Genes Nutr 8(1):79–90

    PubMed  CAS  Google Scholar 

  • Patterson RE, Cadmus LA, Emond JA, Pierce JP (2010) Physical activity, diet, adiposity and female breast cancer prognosis: a review of the epidemiologic literature. Maturitas 66:5–15

    PubMed  Google Scholar 

  • Petrakis NL, Barnes S, King EB, Lowenstein J, Wiencke J, Lee MM (1996) Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal women. Cancer Epidemiol Biomarkers Prev 5:785–794

    PubMed  CAS  Google Scholar 

  • Polyak K, Kalluri R (2010) The role of the microenvironment in mammary gland development and cancer. Cold Spring Harb Perspect Biol 2:a003244

    PubMed  CAS  Google Scholar 

  • Qin LQ, Xu JY, Wang PY, Hoshi K (2006) Soyfood intake in the prevention of breast cancer risk in women: a meta-analysis of observational epidemiological studies. J Nutr Sci Vitaminol 52:428–436

    PubMed  CAS  Google Scholar 

  • Qin W, Zhu W, Shi H, Hewett JE, Ruhlen RL, MacDonald RS et al (2009) Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women. Nutr Cancer 61:238–244

    PubMed  CAS  Google Scholar 

  • Rahal OM, Simmen RC (2010) PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation. Carcinogenesis 31:1491–1500

    PubMed  CAS  Google Scholar 

  • Rahal OM, Simmen RCM (2011) Paracrine-acting adiponectin promotes mammary epithelial differentiation and synergizes with genistein to enhance transcriptional response to estrogen receptor β signaling. Endocrinology 152:3409–3421

    PubMed  CAS  Google Scholar 

  • Rijnkels M, Kabotyanski E, Montazer-Torbati MB, Hue Beauvais C, Vassetzky Y, Rosen JM et al (2010) The epigenetic landscape of mammary gland development and functional differentiation. J Mammary Gland Biol Neoplasia 15:85–100

    PubMed  Google Scholar 

  • Sanchez-Rovira P, Anton A, Barnadas A, Velasco A, Lomas M, Rodriguez-Pinilla M et al (2012) Classical markers like ER and Ki-67, but also survivin and pERK, could be involved in the pathological response to gentacitabine, adriamycin and paclitaxel (GAT) in locally advanced breast cancer patients: results from the GEICAM/2002-01 phase II study. Clin Transl Oncol 14:430–436

    PubMed  CAS  Google Scholar 

  • Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labbat ML et al (2006) Generation of a functional mammary gland from a single stem cell. Nature 439:84–88

    PubMed  CAS  Google Scholar 

  • Shu XO, ** F, Dai Q, Wen W, Potter JD, Kushi LH et al (2001) Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev 10:483–488

    PubMed  CAS  Google Scholar 

  • Shu XO, Zheng Y, Cai H, Gu K, Chen Z, Zheng W et al (2009) Soy food intake and breast cancer survival. JAMA 302:2437–2443

    PubMed  Google Scholar 

  • Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62:10–29

    PubMed  Google Scholar 

  • Simmen FA, Simmen RC (2011) The maternal womb: a novel target for cancer prevention in the era of the obesity pandemic? Eur J Cancer Prev 6:539–548

    Google Scholar 

  • Simmen RC, Eason RR, Till SR, Chatman L Jr, Velarde MC, Geng Y et al (2005) Inhibition of NMU-induced mammary tumorigenesis by dietary soy. Cancer Lett 224:45–52

    PubMed  CAS  Google Scholar 

  • Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H et al (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98:10869–10874

    PubMed  Google Scholar 

  • Spike BT, Engle DD, Lin JC, Cheung SK, La J, Wahl GM (2012) A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell 10:183–197

    PubMed  CAS  Google Scholar 

  • Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T et al (1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95:29–39

    PubMed  CAS  Google Scholar 

  • Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D et al (2006) Purification and unique properties of mammary epithelial stem cells. Nature 439:993–997

    PubMed  CAS  Google Scholar 

  • Su Y, Simmen RC (2009) Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates β-catenin signaling in mammary epithelial cells. Carcinogenesis 30:331–339

    PubMed  Google Scholar 

  • Su Y, Eason RR, Geng Y, Till SR, Badger TM, Simmen RCM (2007a) In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis. Carcinogenesis 28:1046–1051

    PubMed  CAS  Google Scholar 

  • Su Y, Simmen FA, **ao R, Simmen RC (2007b) Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection form mammary tumors. Physiol Genomics 30:8–16

    CAS  Google Scholar 

  • Su Y, Shankar K, Simmen RC (2009) Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes. J Nutr 139:945–951

    PubMed  CAS  Google Scholar 

  • Su Y, Shankar K, Rahal O, Simmen RCM (2011) Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer-preventive actions of dietary factors. J Nutr Biochem 22:605–611

    PubMed  CAS  Google Scholar 

  • Suzuki T, Matsuo K, Tsunoda N, Hirose K, Hiraki A, Kawase T et al (2008) Effect of soybean on breast cancer according to receptor status: a case–control study in Japan. Int J Cancer 123:1674–1680

    PubMed  CAS  Google Scholar 

  • Teas J, Irhimen MR, Druker S, Hurley TG, Hébert JR, Savarese TM et al (2011) Serum IGF-1 concentrations change with soy and seaweed supplements in healthy postmenopausal American women. Nutr Cancer 63:743–748

    PubMed  CAS  Google Scholar 

  • Trock BJ, Hilakivi-Clarke L, Clarke R (2006) Meta-analysis of soy intake and breast cancer risk. J Natl Cancer Inst 98:459–471

    PubMed  CAS  Google Scholar 

  • Tsai CY, Chen YH, Chien YW, Huang WH, Lin SH (2010) Effect of soy saponin on the growth of human colon cancer cells. World J Gastroenterol 16:3371–3376

    PubMed  CAS  Google Scholar 

  • Vaillant F, Asselin-Labat ML, Shackleton M, Forrest NC, Lindeman GJ, Visvader JE (2008) The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res 68:7711–7717

    PubMed  CAS  Google Scholar 

  • Vanhees K, Coort S, Ruijters EJ, Godschalk RW, van Schooten FJ, Barjesteh V et al (2011) Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage. FASEB J 25:797–807

    PubMed  CAS  Google Scholar 

  • Verheus M, van Gils CH, Kreijkamp-Kaspers S, Kok L, Peeters PH, Globee DE et al (2008) Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women. Cancer Epidemiol Biomarkers Prev 17:2632–2638

    PubMed  CAS  Google Scholar 

  • Visvader JE (2009) Kee** abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev 23:2563–2577

    PubMed  CAS  Google Scholar 

  • Wang W, Bringe NA, Berhow MA, de Mejia EJ (2008) Beta-conglycinins among sources of bioactivities in hydrolysates of different soybean varieties that inhibit leukemia cells in vitro. J Agric Food Chem 56:4012–4020

    PubMed  CAS  Google Scholar 

  • Wicha MS, Liu S, Dontu G (2006) Cancer stem cells: an old idea – a paradigm shift. Cancer Res 66:1883–1890

    PubMed  CAS  Google Scholar 

  • Woo HD, Park KS, Ro J, Kim J (2012) Differential influence of dietary soy intake on the risk of breast cancer recurrence related to HER2 status. Nutr Cancer 64:198–205

    PubMed  CAS  Google Scholar 

  • Wu AH, Koh WP, Wang R, Lee HP, Yu MC (2008a) Soy intake and breast cancer risk in Singapore Chinese Health study. Br J Cancer 99:196–200

    PubMed  CAS  Google Scholar 

  • Wu AH, Yu MC, Tseng CC, Pike MC (2008b) Epidemiology of soy exposures and breast cancer risk. Br J Cancer 98:9–14

    PubMed  CAS  Google Scholar 

  • **ao R, Hennings LJ, Badger TM, Simmen FA (2007) Fetal programming of colon cancer in adult rats: correlations with altered neonatal growth trajectory, circulating IGF-I and IGF binding proteins, and testosterone. J Endocrinol 195:79–87

    PubMed  CAS  Google Scholar 

  • **ao R, Su Y, Simmen RC, Simmen FA (2008) Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. Am J Physiol Gastrointest Liver Physiol 294:G868–G876

    PubMed  CAS  Google Scholar 

  • Xu X, Duncan AM, Wangen KE, Kurzer MS (2000) Soy consumption alters endogenous estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomarkers Prev 9:781–786

    PubMed  CAS  Google Scholar 

  • Yamamoto S, Sobue T, Kobayashi M, Sasaki S, Tsugane S, Japan Public Health Center (2003) Soy, isoflavones, and breast cancer risk in Japan. J Natl Cancer Inst 95:901–913

    Google Scholar 

  • Yan L, Spitznagel EL, Bosland MC (2010) Soy consumption and colorectal cancer risk in humans: a meta-analysis. Cancer Epidemiol Biomarkers Prev 19:148–158

    PubMed  CAS  Google Scholar 

  • Yang G, Shu XO, Li H, Chow WH, Cai H, Zhang X et al (2009) Prospective cohort study of soy food intake and colorectal cancer risk in women. Am J Clin Nutr 89:577–583

    PubMed  CAS  Google Scholar 

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Acknowledgments

Work from our laboratories described in this chapter was supported in part by grants from the United States Department of Agriculture-CRIS 6251-5100002, the Department of Defense Breast Cancer Research Program (CDMRP W81XWH-08-0548), the University of Arkansas for Medical Sciences-Translational Research Institute (UL1 RR0298884), and the National Institutes of Health/National Cancer Institute (CA136493). The authors apologize to the many authors of excellent publications on this topic that could not be cited due to space limitations.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children’s Nutrition Center, The Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 15 Children’s Way, Little Rock, AR, 72202, USA

    Rosalia C. M. Simmen

  2. Interdisciplinary Biomedical Sciences Program, Arkansas Children’s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA

    Omar M. Rahal

  3. Department of Physiology and Biophysics, Arkansas Children’s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA

    Maria Theresa E. Montales & John Mark P. Pabona

  4. Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA

    Melissa E. Heard & Ahmed Al-Dwairi

  5. Interdisciplinary Biomedical Sciences Program, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA

    Adam R. Brown

  6. Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, The Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA

    Frank A. Simmen

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Corresponding author

Correspondence to Rosalia C. M. Simmen .

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  1. Dept. Clinical Oncology, Queen Elizabeth Hospital, Gascoigne Road 30, Kowloon, Hong Kong SAR

    William C.S. Cho

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Simmen, R.C.M. et al. (2013). Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer. In: Cho, W. (eds) Cancer Chemoprevention and Treatment by Diet Therapy. Evidence-based Anticancer Complementary and Alternative Medicine, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6443-9_5

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