15 Result(s)
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Open AccessHigh apoptotic endothelial microparticle levels measured in asthma with elevated IgE and eosinophils
While asthma is considered an inflammatory-mediated airway epithelial and smooth muscle disorder, there is increasing evidence of airway capillary endothelial dysfunction associated with vascular remodelling a...
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Open AccessUp-regulation of ACE2, the SARS-CoV-2 receptor, in asthmatics on maintenance inhaled corticosteroids
The first step in SARS-CoV-2 infection is binding of the virus to angiotensin converting enzyme 2 (ACE2) on the airway epithelium. Asthma affects over 300 million people world-wide, many of whom may encounter ...
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Open AccessCREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts
Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrot...
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Open AccessCell-specific expression of lung disease risk-related genes in the human small airway epithelium
The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is known about the molecular phenotypes of the specifi...
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Open AccessCharacterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity
The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining ...
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Open AccessRole of KRAS in regulating normal human airway basal cell differentiation
KRAS is a GTPase that activates pathways involved in cell growth, differentiation and survival. In normal cells, KRAS-activity is tightly controlled, but with specific mutations, the KRAS protein is persistent...
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Open AccessAltered lung biology of healthy never smokers following acute inhalation of E-cigarettes
Little is known about health risks associated with electronic cigarette (EC) use although EC are rising in popularity and have been advocated as a means to quit smoking cigarettes.
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Open AccessSmoking accelerates aging of the small airway epithelium
Aging involves multiple biologically complex processes characterized by a decline in cellular homeostasis over time leading to a loss and impairment of physiological integrity and function. Specific cellular h...
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Open AccessGeneration of a human airway epithelium derived basal cell line with multipotent differentiation capacity
As the multipotent progenitor population of the airway epithelium, human airway basal cells (BC) replenish the specialized differentiated cell populations of the mucociliated airway epithelium during physiolog...
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Open AccessRFX3 Modulation of FOXJ1 regulation of cilia genes in the human airway epithelium
Ciliated cells play a central role in cleansing the airways of inhaled contaminants. They are derived from basal cells that include the airway stem/progenitor cells. In animal models, the transcription factor ...
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Open AccessSmoking-mediated up-regulation of GAD67 expression in the human airway epithelium
The production of gamma-amino butyric acid (GABA) is dependent on glutamate decarboxylases (GAD65 and GAD67), the enzymes that catalyze the decarboxylation of glutamate to GABA. Based on studies suggesting a r...
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Open AccessDisparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers
The small airway epithelium and alveolar macrophages are exposed to oxidants in cigarette smoke leading to epithelial dysfunction and macrophage activation. In this context, we asked: what is the transcriptome...
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Open AccessInfluence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Infections of the respiratory tract are a hallmark in CF. The host immune responses in CF are...
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Open AccessUpregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis
Cigarette smoke disrupts the protective barrier established by the airway epithelium through direct damage to the epithelial cells, leading to cell death. Since the morphology of the airway epithelium of smoke...
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Strategies for aerosol therapy ofα 1-antitrypsin deficiency by the aerosol route
α1-antitrypsin (AAT) deficiency is a genetic disease in which low serum and lung levels of the antiprotease AAT cause a deficiency of the anti-elastase defensive screen of the lower respiratory tract such that n....
