Skip to main content

2 Result(s)

within Shyam Nathan Remove this filter

and

  1. Article

    Open Access

    CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts

    Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrot...

    Shyam Nathan, Haijun Zhang, Mirko Andreoli, Philip L. Leopold… in Respiratory Research (2021)

    Download PDF (2300 KB) View Article

  2. No Access

    Article

    BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor-α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer cells

    We previously identified small molecules that fit into a BRCA1-binding pocket within estrogen receptor-alpha (ERα), mimic the ability of BRCA1 to inhibit ERα activity (“BRCA1-mimetics”), and overcome antiestro...

    Shyam Nathan, Yongxian Ma, York A. Tomita… in Breast Cancer Research and Treatment (2017)