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  1. No Access

    Article

    Discovery of bioactive microbial gene products in inflammatory bowel disease

    Microbial communities and their associated bioactive compounds1–3 are often disrupted in conditions such as the inflammatory bowel diseases (IBD)4. However, even in well-characterized environments (for example, t...

    Yancong Zhang, Amrisha Bhosle, Sena Bae, Lauren J. McIver, Gleb Pishchany… in Nature (2022)

  2. Article

    Open Access

    Identifying novel associations in GWAS by hierarchical Bayesian latent variable detection of differentially misclassified phenotypes

    Heterogeneity in the definition and measurement of complex diseases in Genome-Wide Association Studies (GWAS) may lead to misdiagnoses and misclassification errors that can significantly impact discovery of di...

    Afrah Shafquat, Ronald G. Crystal, Jason G. Mezey in BMC Bioinformatics (2020)

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  3. Article

    Open Access

    Role of KRAS in regulating normal human airway basal cell differentiation

    KRAS is a GTPase that activates pathways involved in cell growth, differentiation and survival. In normal cells, KRAS-activity is tightly controlled, but with specific mutations, the KRAS protein is persistent...

    Fumihiro Ogawa, Matthew S. Walters, Afrah Shafquat… in Respiratory Research (2019)

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  4. No Access

    Article

    Sequencing and beyond: integrating molecular 'omics' for microbial community profiling

  5. Advances in DNA sequencing have enabled culture-independent profiling of microbial community membership and function — the field of metagenomics. These approac...

    6. Eric A. Franzosa, Tiffany Hsu, Alexandra Sirota-Madi… in Nature Reviews Microbiology (2015)