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Article
Open AccessReduced frequency of migraine attacks following coronavirus disease 2019: a case report
Severe acute respiratory syndrome coronavirus 2 is a virus affecting different organs and causing a wide variety and severity of symptoms. Headache as well as loss of smell and taste are the most frequently re...
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Article
Investigation of the RB1-SOX2 axis constitutes a tool for viral status determination and diagnosis in Merkel cell carcinoma
MCC (Merkel cell carcinoma) is an aggressive neuroendocrine cutaneous neoplasm. Integration of the Merkel cell polyomavirus (MCPyV) is observed in about 80% of the cases, while the remaining 20% are related to...
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Article
Open AccessAuthor Correction: Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression
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Article
Open AccessIFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression
Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associa...
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Article
Open AccessElucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells
Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further improvement of this therapeutic approach. Here, we compared the mode of action of romidepsi...
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Article
Open AccessBRAF inhibition causes resilience of melanoma cell lines by inducing the secretion of FGF1
Approximately half of all melanoma patients harbour activating mutations in the serine/threonine kinase BRAF. This is the basis for one of the main treatment strategies for this tumor type, the targeted therap...
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Article
Detection of the Merkel cell polyomavirus in the neuroendocrine component of combined Merkel cell carcinoma
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin. The main etiological agent is Merkel cell polyomavirus (MCPyV), detected in 80% of cases. About 5% of cases, called combined M...
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Article
Open AccessMembrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression
The serine/threonine kinase LKB1 regulates various cellular processes such as cell proliferation, energy homeostasis and cell polarity and is frequently downregulated in various tumours. Many downstream pathwa...
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Article
P53 mutation is a rare event in Merkel cell carcinoma of the head and neck
The aim of this retrospective analysis was to evaluate the status of p53 and possible mutations in Merkel cell carcinoma (MCC) cell lines and MCC tissue samples. The p53 mutations are common in different cance...
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Chapter
Pathogenesis of Merkel Cell Carcinoma
Despite a substantial research effort, the understanding of the molecular basis of MCC is still limited. Overexpression of the anti-apoptotic molecule bcl-2 was observed in three-fourths of MCC tumors in two i...
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Article
Impact of the CCR5 gene polymorphism on the survival of metastatic melanoma patients receiving immunotherapy
Chemokines influence both tumor progression and anti-tumor immune response. A 32-bp-deletion polymorphism in the chemokine receptor 5 gene (CCR5Δ32) has been shown to result in a non-functional protein. This s...
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Article
Dendritic cell based antitumor vaccination: impact of functional indoleamine 2,3-dioxygenase expression
Recent reports have demonstrated that the enzyme indoleamine 2,3-dioxygenase (IDO) is upregulated in human dendritic cells (DCs) upon in vitro maturation. IDO is supposed to convey immunosuppressive effects by...
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Article
Open AccessThe carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report
Since tacrolimus ointment was approved by the U.S. Food and Drug Administration (FDA) as a promising treatment for atopic dermatitis, it has been approved in more than 30 additional countries, including numero...
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Chapter and Conference Paper
Vom Nävus zum Melanom
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Article
Regulation of c-myc expression by Ras/Raf signalling
The c-myc gene is induced upon growth factor stimulation of arrested cells. The interaction of a mitogen with a transmembrane receptor triggers a variety of parallel signal transduction cascades. In order to anal...
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Article
Production of purified alginates suitable for use in immunoisolated transplantation
Alginate is used as a matrix for immunoisolation of cells and tissues in vivo. We have demonstrated previously that commercial alginates contain various fractions of mitogenic impurities and that they can be r...
