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Article
The immunodominant HLA-A2-restricted MART-1 epitope is not presented on the surface of many melanoma cell lines
Among the relatively large number of known tumor-associated antigens (TAA) which are recognized by human CD8 T-cells, Melan-A/MART-1 is one of the most—if not the most—frequently used target for anti-cancer va...
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Article
Immunological tumor destruction in a murine melanoma model by targeted LTα independent of secondary lymphoid tissue
We previously demonstrated that targeting lymphotoxin α (LTα) to the tumor evokes its immunological destruction in a syngeneic B16 melanoma model. Since treatment was associated with the induction of peritumor...
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Article
Dendritic cell based antitumor vaccination: impact of functional indoleamine 2,3-dioxygenase expression
Recent reports have demonstrated that the enzyme indoleamine 2,3-dioxygenase (IDO) is upregulated in human dendritic cells (DCs) upon in vitro maturation. IDO is supposed to convey immunosuppressive effects by...
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Article
Therapeutic efficacy of tumor-targeted IL2 in LTα−/− mice depends on conditioned T cells
An effective immunological eradication of tumors by the adaptive immune system depends on T cell priming, expansion of specific T cells and their effector function. It has been shown that either step may be im...
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Article
IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice
Immunity to infection with intracellular pathogens is regulated by interleukin 12 (IL-12), which mediates protective T helper type 1 (TH1) responses, or IL-4, which induces TH2 cells and susceptibility. Paradoxic...
