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Article
Open AccessHealth equity, care access and quality in headache – part 2
Headache disorders are a global public health concern affecting diverse populations. This review examines headache service organizations in low-, middle-, and high-income countries. It addresses global challen...
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Article
Open AccessThe effect of erenumab on brain network function in episodic migraine patients: a randomized, placebo-controlled clinical trial (RESET BRAIN)
We aimed to explore whether erenumab, a monoclonal antibody targeting the calcitonin gene-related peptide receptor, could exert a central effect on brain network function in migraine, and investigate the persi...
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Article
Open AccessTracking the evolution of non-headache symptoms through the migraine attack
The migraine attack is classically divided into the prodromal, aura, headache and postdromal phase. Previous studies have highlighted non-headache symptoms associated with migraine occurring during the prodrom...
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Article
Conversion from chronic to episodic migraine in patients treated with galcanezumab in real life in Italy: the 12-month observational, longitudinal, cohort multicenter GARLIT experience
To investigate in real-life the conversion from chronic migraine (CM) to episodic migraine (EM), specifically to EM with High-Frequency (HFEM: 8–14 monthly migraine days, MMDs), Medium-Frequency (MFEM, 4–7 MMD...
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Article
Open AccessPredictors of response to anti-CGRP monoclonal antibodies: a 24-week, multicenter, prospective study on 864 migraine patients
The identification of predictors of response to antiCGRP mAbs could favor tailored therapies and personalized treatment plans. This study is aimed at investigating predictors of ≥ 50%, ≥ 75% and 100% response ...
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Article
Comparison of efficacy and safety of erenumab between over and under 65-year-old refractory migraine patients: a pivotal study
Previous studies reported a positive effect of anti-CGRP monoclonal antibodies (mAbs) in migraine prevention, either in over (O65) and under (U65) 65-year-aged patients. The aim of our study was to evaluate an...
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Article
Open AccessDiscontinuing monoclonal antibodies targeting CGRP pathway after one-year treatment: an observational longitudinal cohort study
Monoclonal antibodies anti-calcitonin gene-related peptide (mAbs anti-CGRP) pathway are effective and safe on migraine prevention. However, some drug agencies limited these treatments to one year due to their ...
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Article
Neural correlates of visuospatial processing in migraine: does the pain network help?
Migraine patients frequently report cognitive symptoms during the different phases of migraine. The most affected cognitive domains are visuospatial abilities, processing speed, attention and executive functio...
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Article
Tension-type headache
Tension-type headache (TTH) is the most prevalent neurological disorder worldwide and is characterized by recurrent headaches of mild to moderate intensity, bilateral location, pressing or tightening quality, ...
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Article
Stress in paediatric migraine: a trigger factor?
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Article
Candesartan in migraine prevention: results from a retrospective real-world study
Randomized studies have reported a positive effect of candesartan, an angiotensin II receptor antagonist, in migraine prevention. The aim of our study was to explore patient subjective efficacy of candesartan ...
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Article
Dysregulation of multisensory processing stands out from an early stage of migraine: a study in pediatric patients
Resting state (RS) functional connectivity (FC) abnormalities of brain networks involved in pain- and multisensory processing have been disclosed in adult-migraine patients. We explored RS FC of large-scale br...
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Article
Imaging the migrainous brain: the present and the future
In the last 20 years, we observed significant improvements in the use of magnetic resonance imaging (MRI) for the evaluation of patients affected by migraine. Before these technological advances, knowledge of ...
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Article
Open AccessRelation between characteristics of carotid atherosclerotic plaques and brain white matter hyperintensities in asymptomatic patients
White matter hyperintensities (WMH) can be incidentally found in patients with carotid atherosclerosis on brain magnetic resonance imaging (MRI). We investigated the relationship between WMH and characteristic...
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Article
Open AccessAn update on migraine: current understanding and future directions
Migraine is a common brain disorder with high disability rates which involves a series of abnormal neuronal networks, interacting at different levels of the central and peripheral nervous system. An increase i...
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Article
Structural brain abnormalities in patients with vestibular migraine
New advances in understanding the pathophysiology of vestibular migraine (VM) have suggested a large overlap between migraine and vestibular pathways. We explored the regional distribution of gray (GM) and whi...
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Article
Refractory chronic migraine: is drug withdrawal necessary before starting a therapy with onabotulinum toxin type A?
Onabotulinum toxin A (BT-A) is now one of the authorized prophylaxis treatments for chronic migraine (CM) thanks to previous clinical trials, which usually required a pharmacologic washout as a precondition fo...
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Protocol
fMRI of Pain
Pain was first considered to be a hard-wired system in which noxious input was passively transmitted along sensory channels to the brain. However, today it is generally accepted that the experience of pain is ...
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Protocol
fMRI of the Sensorimotor System
The extensive application of fMRI to the assessment of the human sensorimotor system has disclosed a complexity that is largely beyond our original understanding. From the available data, it is accepted that t...
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Article
Resting-state fMRI functional connectivity: a new perspective to evaluate pain modulation in migraine?
Resting-state (RS) functional magnetic resonance imaging (fMRI) is a relatively novel tool which explores connectivity between functionally linked, but anatomically separated, brain regions. The use of this te...
